A new strategy for targeted delivery of non-water-soluble porphyrins in chitosan-albumin capsules

Selective Metal‐Complexation on Polymeric Templates and Their Investigation via Isothermal Titration Calorimetry

“…[38] 4. Experimental Section 5,10,15,20-tetraphenylporphyrin, [39] 4-(10,15,20-triphenylporphyrin-5yl)aniline, [40] and 6-([2,2":6",2""-terpyridin]-4'-yloxy)hexanoic acid [29] were synthesized according to already published procedures. A detailed list of the used materials and instrumentation can be viewed in the Supporting Information.…”

Synthesis and Photophysical Properties of Low Symmetrical Porphyrin-Amino Acid Conjugates and Their Zn Complexes

“…Method A. [16] A mixture of 250 mg (0.4 mmol) 5-(4′-aminophenyl)-10,15,20-triphenylporphine 3, 154 mg (0.9 mmol) N-(tert-butoxycarbonyl)glycine, 173 mg (0.85 mmol) 1-(3′-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride, and 0.1 ml (0.44 mmol) triethylamine in 80 ml of dichloromethane was stirred at 0 °C for 1 h. The reaction mixture was allowed to warm up to room temperature and then was stirred for 3 h. The solvent was evaporated to dryness and the residue was purified by flash chromatography using DCM as the elu- General procedure to synthesis porphyrin-amino acid conjugates 4b-e. [17] A mixture of corresponding amounts of aminophenylporphyrin 3, corresponding Boc-protected amino acids, of DMAP and of EDC in 15 ml of anhydrous dichloromethane was magnetically stirred for 1.5 h with cooling in an ice bath and then at ambient temperature until the completion of the reaction according to TLC. The resulting solution was subjected to column chromatography on silica with methylene chloride as an eluent.…”

“…Firstly, H 2 TPP was regioselective nitrated using equimolar amounts of the sodium nitrite and H 2 TPP in triflouracetic acid by stirring at 0 o C as described by us earlier. [16] The reduction of nitro group in porphyrin 2 was carried out with SnCl 2 •2H 2 O in concentrated HCl by heating of the reaction mixture at 65 o C during 1h. Column chromatography on silica gel for purification of both porphyrins 2 and 3 was used.…”

FRET‐Amplified Singlet Oxygen Generation by Nanocomposites Comprising Ternary AgInS2/ZnS Quantum Dots and Molecular Photosensitizers

“…Furthermore, due to the presence of a large number of hydroxyl and amino groups in its structure, CS can be chemically conjugated with photosensitizing agents [24–27] . For example, CS can be used as a matrix for hydrophobic porphyrin molecules, increasing their water solubility, [28,29] as well as it can effectively bind negatively charged nanoparticles [30,31] …”