A new synthesis of 3-aryl substituted oxindoles

Convenient Synthesis of 3-Alkoxy-3-aryloxindoles by Intramolecular Arylation of Mandelic Amides

“…The most commonly employed methods for the synthesis of this motif are the addition of aryl nucleophiles to isatins (Grignard reagents and boronic acids), inter- and intramolecular Friedel−Crafts hydroxyalkylations, oxidative hydroxylation of 3-aryloxindoles, and S N Ar reactions of 2-fluoronitroarenes on dioxolanone templates . Asymmetric variants of many of these approaches are known. ,,, …”