A new synthesis of phthalimidines

Abstract

A new synthesis of phthalimidines is described. 3 Acyloxy 2 aryl and 2 acylamino 3 acyloxyphthalimidines were prepared by the reaction of 3 arylaminophthalides or o formylbenzoic acid acylhydrazones with acetic or propionic anhydrides. Their reactions with O , N , S , and C nucleophiles were studied. The structure of 2 acetyl(cyanoacetyl)amino 3 acetoxyindolin 1 one was confirmed by X ray diffraction analysis.Key words: о formylbenzoic acid, 3 arylaminophthalides, o formylbenzoic acid acyl hydrazones, acetic and propionic anhydrides, 3 acyloxy 2 aryl phthalimidines, 2 acyl amino 3 acyloxyphthalimidines, X ray diffraction analysis.