A new tactic to treat postprandial hyperlipidemia in diabetic rats with gastroparesis by improving gastrointestinal transit

Xie, Weidong; Xing, Dongming; Zhao, Yunan; Su, Hui; Meng, Zhen; Chen, Yunyun; Du, Lijun

doi:10.1016/j.ejphar.2005.01.019

Cited by 34 publications

(27 citation statements)

References 20 publications

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“…SAP patients admitted to our intensive care unit were given purgatives, such as magnesium sulfate, Mannitol, lactulose and Dachengqi decoction(Chinese h e r b a l m e d i c i n e ) . T h e s e d r u g s c o u l d p r o m o t e gastrointestinal motility, ameliorate intestinal permeability and decrease bacterial translocation [26,27] . They can also improve bile discharge and decrease effusion in the abdominal cavity.…”

Section: Discussionmentioning

confidence: 99%

Severe acute pancreatitis in the elderly: Etiology and clinical characteristics

Xin¹,

Hong²,

Luo³

et al. 2008

WJG

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AIM:To investigate the etiology and clinical characteristics of severe acute pancreatitis (SAP) in elderly patients (≥ 60 years of age). METHODS:We reviewed retrospectively all the SAP cases treated in Xuanwu Hospital in Beijing between 2000 and 2007. RESULTS:In 169 patients with SAP, 94 were elderly and 16 died. Biliary and idiopathic etiologies were the first two causes that accounted for over 90% of SAP in the elderly. Biliary, hyperlipemic and alcoholic etiologies were the first three causes in the young. The proportion of comorbidity of cholelithiasis, biliary infection, hypertension and coronary heart disease in the aged was significantly higher than that in their young partners. The scores of APACHE Ⅱ and Ranson were also significantly higher in the elderly except the CT score. Organ failures were more common in the elderly, but the local pancreatic complications were not different between the two groups. Mortality of the aged was correlated with the severity of SAP, multiple co-morbidity and incidence of multiple organ dysfunction syndrome (MODS). MODS was the main cause of death. CONCLUSION:The etiology of SAP in the elderly is quite different from that in the young. Biliary and unknown factors are main causes in the aged. The elderly are subject to major organ failures but there is no difference in the occurrence of local pancreatic complications between the elderly and the young. It is crucial to monitor and improve the functions of major organs so as to prevent MODS in the aged with SAP.

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Section: Discussionmentioning

confidence: 99%

Severe acute pancreatitis in the elderly: Etiology and clinical characteristics

Xin¹,

Hong²,

Luo³

et al. 2008

WJG

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“…Berberine (BBR) is widely used as a non-prescription oral drug in China to treat gut infections and diarrhea, and its benefi cial effects in the treatment of diabetes (Ni, 1988) and dyslipidaemia (Kong et al, 2004) in humans have been reported. Previous studies have shown BBR has hypolipidemic and hypoglycaemic effects through improvement of gastrointestinal transit and upregulation of L-type calcium channel expression (Xie et al, 2005;Zhao et al, 2009). Pre-clinical experimental results have demonstrated that BBR has cardioprotective effects in MI, and BBR has been used in diabetic patients with ischemic cardiomyopathy.…”

Section: Introductionmentioning

confidence: 96%

Berberine elicits anti‐arrhythmic effects via IK1/Kir2.1 in the rat type 2 diabetic myocardial infarction model

Wang

et al. 2010

Phytotherapy Research

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The purpose of this study was to explore the anti-arrhythmic mechanisms of berberine in diabetic rats with myocardial infarction. Sixty rats were divided into four groups: (1) normal control; (2) myocardial infarction group (MI); (3) Type 2 diabetes with myocardial infarction group (T2DM+MI); and (4) Type 2 diabetic with myocardial infarction berberine-treated group (BBR). Berberine (60 mg/kg/day) was administered after coronary artery ligation in the T2DM+MI group for 14 days. Currents were measured using whole-cell patch-clamp techniques. Western blot was performed for quantification of target proteins. The study showed that arrhythmias induced by myocardial infarction were aggravated in diabetic rats. Arrhythmia scores in the MI group were significantly higher than in the control group. Interestingly, the administration of berberine at a dose of 60 mg/kg/d recovered arrhythmia scores (P > 0.05). RMP (Resting membrane potential) which could be recovered by berberine (P < 0.05), was significantly reduced in both the infarction groups. I(K1) current and current density markedly decreased in the MI and T2DM+MI groups (P < 0.05) and could be reversed by berberine (P < 0.05). The relative expression of Kir2.1 in rats in the MI and T2DM+MI group were both significantly decreased (P < 0.05); berberine recovered depressed Kir2.1 to nearly normal levels. The results suggest that the effects of berberine on I(K1)/Kir2.1 may be an important mechanism for producing anti-arrhythmic effects.

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“…administration of alloxan (150 mg / kg body weight) as previously prescribed (9). Induction of diabetic hypercholesterolemia in mice was according to the previous method (10) with a slight modification, that is, diabetic mice were allowed free access to a high-fat diet (84.3% standard laboratory chow, 5% lard, 10% yolk powder, 0.2% cholesterol, 0.5% bile salt).…”

Section: Animalsmentioning

confidence: 99%

Hypolipidemic Mechanisms of Ananas comosus L. Leaves in Mice: Different From Fibrates but Similar to Statins

Xie

Wang

et al. 2007

J Pharmacol Sci

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Abstract. In this study, we investigated hypolipidemic mechanisms of the ethanolic extract of Ananas comosus L. leaves (AC) in mice and then determined its activities in related enzymes. The results showed that AC (0.40 g / kg) significantly inhibited the increase in serum triglycerides by 40% in fructose-fed mice. In mice induced by alloxan and high-fat diets, serum total cholesterol remained at a high level (180 -220 mg / dl) within 7 days of removing high-fat diets but reached normal level (120 -140 mg / dl) after AC (0.40 g / kg per day) treatment. Also, AC (0.40 and 0.80 g / kg) significantly inhibited serum lipids from the increase in Triton WR-1339-induced hyperlipidemic mice. AC (0.01 -100 µg / ml) selectively activated lipoprotein lipase (LPL) activity by 200% -400% and significantly inhibited 3-hydroxyl-methyl glutaryl coenzyme A (HMGCoA) reductase activity by 20% -49% in vitro. Furthermore, 2 months of fenofibrate (0.20 g / kg) administration particularly increased mice liver weights (0.0760 ± 0.0110 g / g) while AC (0.40 g / kg) had no effect (0.0403 ± 0.0047). Taken together, these results suggest that AC will be a new potential natural product for the treatment of hyperlipidemia that exerts its actions through mechanisms of inhibiting HMGCoA reductase and activating LPL activities. Its action mechanisms differentiate from those with fibrates but may be partly similar to those with statins. It is hopeful that AC may serve as the adjuvant for fibrates.

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A new tactic to treat postprandial hyperlipidemia in diabetic rats with gastroparesis by improving gastrointestinal transit

Cited by 34 publications

References 20 publications

Severe acute pancreatitis in the elderly: Etiology and clinical characteristics

Severe acute pancreatitis in the elderly: Etiology and clinical characteristics

Berberine elicits anti‐arrhythmic effects via IK1/Kir2.1 in the rat type 2 diabetic myocardial infarction model

Hypolipidemic Mechanisms of Ananas comosus L. Leaves in Mice: Different From Fibrates but Similar to Statins

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