“…It is synthesized in endoplasmic reticulum (ER)-attached ribosomes followed by its import into ER where it is glycosylated and modified by GPI anchor before it is transported into Golgi for further modification. Then PrP C is transported to the cell surface where it can be internalized through endocytic pathway (7). The internalized PrP C can be transported into the lysosome for degradation or be enclosed in exosomes and secreted Abbreviations: Bax, Bcl-2-associated X protein; Bcl, B cell leukemia oncogene; CRC, Colorectal cancer cell; CSC, Cancer stem cell; EMT, Epithelial-Mesenchymal Transition; ERK, Extracellular-signal-regulated kinase; 5-FU, 5-fluorouracil; GBM, Glioblastomas; GPI, Glycosylphosphatidylinositol; HOP, Hsp70/90 organizing protein; HSCs, Hematopoietic stem cells; MDR, Multi-drug resistance; MET, Mesenchymal-to-epithelial transition; MMP11, Matrix metalloproteinase-11; MSCs, Mesenchymal stem cells; Oct4, Octamer-binding transcription factor 4; 1-OPRD, One octapeptide repeat deletion; PDAC, Pancreatic ductal adenocarcinoma; P-gp, P-glycoprotein; PI3K, Phosphatidylinositol 3 kinase; PrP C , Cellular prion protein; PrP Sc , Scrapie prion protein; PrP C -AptDOa, PrP C -Apt-functionalized doxorubicin-oligomer-AuNPs; SATB1, Special AT-rich sequence-binding proteins 1; SOD, Superoxide dismutase; TIMP, Tissue Inhibitor of Metalloproteinase; TNF-a, Tumor Necrosis Factor-a; TRAIL, Tumor necrosis factor-related apoptosis-inducing ligand; UPR, Unfolded protein response.…”