A New Therapy for Prevention of Post-operative Recurrences in Genital and Breast Cancer

Loeser, Arnold

doi:10.1136/bmj.2.4901.1380

Cited by 76 publications

(35 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Six of the 13 statistically evaluable studies (46%) showed a significant association between HT and BrCa (RR=1.40, CI=1.29-1.53, P<0.022, by Fisher's exact test) 11,[13][14][15][16]18 . These results were perti- n=6; N=1,431 subjects against BrCa, whereas women who had undergone subtotal thyroidectomy developed BrCa more often than expected and, thus, recommended administration of thyroid hormone as a treatment for BrCa 43 . This author also postulated that the lack of thyroid hormones permitted the development of malignant cells within the mammary epithelium 43 .…”

Section: Resultsmentioning

confidence: 86%

Lack of association between Hashimoto thyroiditis and breast cancer: A quantitative research synthesis

Sarlis¹,

Gourgiotis²,

Pucino³

et al. 2002

View full text Add to dashboard Cite

Several authors have suggested a positive association between Hashimoto thyroiditis (HT) and breast cancer (BrCa). Others have refuted these findings; hence, this subject remains controversial. We therefore reviewed the world literature on this subject accumulated over the last 50 years and performed a quantitative research synthesis, a meta-analysis variant. The incidence risk ratios and 95% confidence intervals (CI's) were calculated for each study and the combined relative risk (RR) was estimated. We found 37 relevant studies, of which only 13 were accessible to analysis. A significant association (RR=1.40; CI=1.29-1.53, P<0.022) was found for 6 of the 13 studies pertaining to 1,431 women. However, in the cumulative population of 14,226 women (from all 13 studies), we failed to demonstrate an association between the diagnoses of HT and BrCa (RR=1.07; CI=0.99-1.15; P=0.08). In conclusion, we believe that selection bias or institutional referral bias, in at least some of the "positive" studies, may have led to the spurious recognition of an association between HT and BrCa, especially as both of these conditions are highly prevalent in women between the 4th and 7th decade of life.

show abstract

Section: Resultsmentioning

confidence: 86%

Lack of association between Hashimoto thyroiditis and breast cancer: A quantitative research synthesis

Sarlis¹,

Gourgiotis²,

Pucino³

et al. 2002

View full text Add to dashboard Cite

show abstract

“…Further, one of us observed that in hyperthyroid women there is a lower incidence of malignant growth of the breast than among the average female population, and discussed the possibility of a relationship between tendency to malignant growth and histamine content of the tissues (Loeser, 1953(Loeser, , 1954a.So far Harris (1927) seems to be the only author who has made a more detailed determination of the histamine equivalent of extracts prepared from human skin by assaying their depressor action on the cat's arterial blood pressure against histamine. The histamine equivalent of skin samples taken from nine breasts was found to be between 5-7 and 7-6, and from three thighs between 8 and 8'8 pug/g.…”

mentioning

confidence: 99%

Histamine content of human skin in different clinical disorders

Feldberg¹,

Loeser²

1954

The Journal of Physiology

Self Cite

View full text Add to dashboard Cite

Little is known about the part histamine plays in different non-allergic disorders, although there are some observations on animals suggesting a correlation between tissue histamine and thyroid activity (Goltz & Dragstedt, 1940;Hoffmann & Hoffmann, 1944). Further, one of us observed that in hyperthyroid women there is a lower incidence of malignant growth of the breast than among the average female population, and discussed the possibility of a relationship between tendency to malignant growth and histamine content of the tissues (Loeser, 1953(Loeser, , 1954a.So far Harris (1927) seems to be the only author who has made a more detailed determination of the histamine equivalent of extracts prepared from human skin by assaying their depressor action on the cat's arterial blood pressure against histamine. The histamine equivalent of skin samples taken from nine breasts was found to be between 5-7 and 7-6, and from three thighs between 8 and 8'8 pug/g. The number of his cases was rather small and in our greater number of patients more individual variation in the histamine equivalent of skin was found than was to be expected from his results. METHODSThe skin was removed during operations or excised under local anaesthesia and transported, straight after removal, from the operating theatre to the laboratory, where it was freed from loose subcutaneous tissue and fat, weighed, and minced in a mortar with a little sand and acidified (HCI) 0-9 % NaCl solution. The samples weighed between 30 and 300 mg. The minced extracts were boiled for a minute, filtered, neutralized with NaOH, and assayed against histamine on the atropinized guinea-pig's ileum preparation. All histamine values refer to the base. The time between removal of the skin and extraction was usually less than 1 hr. Sometimes the skin of the same patient was re-examined after special treatment. Table 1 summarizes the results obtained, in the course of 40 months, from forty-nine patients, arranged in ascending order of histamine values which vary between 1V8 and 26-7 ,ug/g (mean 8-8 ,g/g). All skin samples except two were from women. RESULTS

show abstract

“…showed surprisingly low 24-hour 131J uptakes (6 and 12 respectively) not increased by TSH stimulation. Although according to Loeser (1954) one might have expected these to benefit from thyroid or T3 administration, yet they showed no regression of tumour on combined therapy.…”

Section: Discussionmentioning

confidence: 99%

“…Several recent papers have investigated a possible relationship between the incidence of breast cancer and decreased activity of the thyroid gland (Loeser, 1954;Sommers, 1955;Ellerker, 1956;Rawson, 1956;Edelstyn, Lyons and Welbourn, 1958;Marques, Bru and Espinosse, 1959;Hortling, Hilsi-Brummer and Bjorresten, 1959;Finley and Bogardus, 1960;Carter and Feldman, 1960;Reeve et al, 1961 ;Sicher and Waterhouse, 1961). The relationship has been investigated by demographic, biochemical and experimental approaches.…”

Section: Discussionmentioning

confidence: 99%

“…It was therefore noteworthy when Loeser (1954) suggested that thyroid administration may protect against recurrence of breast cancer and that the combination of male hormone with thyroid extract yielded greater clinical benefit than the male hormone alone in mammary carcinoma. This suggestion was not followed up by others until Bacigalupo (1959) and Luehrs (1959, 1 960a) and Luehrs and Bacigalupo (1960) reported on the administration of 120 microgrammes daily of tri-iodothyronine (T3) with androgen (Durabolin).…”

mentioning

confidence: 99%

See 1 more Smart Citation

A Clinical Trial of Tri-Iodothyronine as a Hormone Potentiator in Advanced Breast Cancer

Stoll¹

1962

Br J Cancer

View full text Add to dashboard Cite

A New Therapy for Prevention of Post-operative Recurrences in Genital and Breast Cancer

Cited by 76 publications

References 2 publications

Lack of association between Hashimoto thyroiditis and breast cancer: A quantitative research synthesis

Lack of association between Hashimoto thyroiditis and breast cancer: A quantitative research synthesis

Histamine content of human skin in different clinical disorders

A Clinical Trial of Tri-Iodothyronine as a Hormone Potentiator in Advanced Breast Cancer

Contact Info

Product

Resources

About