A new thio-Schiff base fluorophore with copper ion sensing, DNA binding and nuclease activity

Vikneswaran, R.; Syafiq, Muhamad Syamir; Eltayeb, Naser Eltaher; Kamaruddin, Mohd Naqiuddin; Subramaniam, Ramesh; Yahya, Rosiyah

doi:10.1016/j.saa.2015.05.087

Cited by 14 publications

(2 citation statements)

References 40 publications

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“…However, when plasmid DNA is treated with 1 or 2 in the presence of H 2 O 2 , DNA cleavage occurs (evident from the formation of Form II). To identify the intermediate reactive oxygen species involved in the DNA cleavage, various scavenging agents (hydroxyl radical scavenger, DMSO; superoxide scavenger, KI; singlet oxygen scavenger, NaN 3 ) were added to the reaction mixtures . As shown in Fig.…”

Section: Resultsmentioning

confidence: 99%

New anticancer zinc(II) complexes comprising thiosemicarbazones of saturated ring: structure, DNA/protein binding, DNA cleavage, topoisomerase‐1 inhibition and anti‐proliferation studies

Vikneswaran

Eltayeb

Subramaniam

et al. 2016

Applied Organom Chemis

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The reaction of the thiosemicarbazones (CH2)4CNN(H)C(S)NHR (R = H, Me) with zinc(II) acetate in methanolic solution proceeds readily under mild conditions to form stable mononuclear complexes Zn[(CH2)4CNNC(S)NHR]2. DNA interaction studies show that the zinc(II) complexes bind to DNA via groove mode and exhibit efficient DNA cleavage activity in the presence of hydrogen peroxide. Also, the complexes display a binding affinity to bovine serum albumin protein with KBSA values of ca 105 M−1. Topoisomerase catalytic inhibition studies suggest that both complexes are efficient topoisomerase‐I impeders. Furthermore, the anti‐proliferative effects of the two complexes on five human tumor cell lines (Caki‐2, MCF‐7, CaSki, NCI‐H322M and Co‐115) indicate that both complexes have the potential to act as effective anticancer drugs. Copyright © 2016 John Wiley & Sons, Ltd.

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Section: Resultsmentioning

confidence: 99%

New anticancer zinc(II) complexes comprising thiosemicarbazones of saturated ring: structure, DNA/protein binding, DNA cleavage, topoisomerase‐1 inhibition and anti‐proliferation studies

Vikneswaran

Eltayeb

Subramaniam

et al. 2016

Applied Organom Chemis

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“…[25] Nevertheless, the real time monitoring methods like colorimetric and fluorimetric methods have received unprecedented attention due to remarkable sensitivity and selectivity, quick response, easy signal read-out, cost effectiveness, and easy sample preparation. [26] The colorimetric method is a facile approach involving detection of color change of analyte with naked eye discernibility without the aid of expensive instruments, while fluorimetric methods are also extremely attractive due to ease of measurement and intrinsic sensitivity and selectivity. [27,28] Fluorescent chemosensors also known as fluoro-ionophores, basically consist of ionophore (recognition moiety) required for selective binding of substrate and fluorophore (transducting moiety) for providing means of signaling this binding, either by fluorescence quenching or enhancement linked through spacer.…”

Section: Introductionmentioning

confidence: 99%

Intriguing interactions of triazolyl organosilane with copper (II) ion, blue copper protein, and silica nanoparticles: Spectral and theoretical approach

Singh

Kaur

Pawan

et al. 2022

Applied Organom Chemis

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In this manuscript, a concise library of 2‐Amino‐4‐chlorophenol‐based organosilanes 5(a‐c) was designed and synthesized by employing a multistep strategy and characterized with the help of NMR (1H and 13C) spectroscopic and mass spectrometry techniques. The silica nanoparticles loaded with 5a have been successfully synthesized and confirmed with the help of various techniques. Further, the interaction of probes 5a and its hybrid silica nanoparticles (A‐NPs) have been investigated towards various metal ions and exhibited favorable selectivity towards Cu2+ ions over other common metal ions in methanol with both colorimetric and fluorimetric read‐outs. The binding of probes 5a and A‐NPs with Cu2+ can be monitored by change of color in daylight and also by turn‐off fluorescence response in UV light. The sensing mechanism is ascribed to paramagnetic nature of Cu2+ ion leading to ligand to metal charge transfer and, hence, shows chelation enhanced fluorescence quenching (CHEQ) effect in the vicinity of ligands 5a and A‐NPs. The results demonstrated that the hybrid nanocomposites (A‐NPs) has even lower limit of detection and higher binding affinity as compared to probe 5a. The possible mechanism of 1:1 binding of 5a with Cu2+ could be substantiated by the density functional theory. Thus, this facile and appropriate sensing strategy may serve as a promising tool for selective and sensitive detection of Cu2+ ions. Moreover, the molecular docking studies provide valuable information regarding the interaction of compound 5a with the blue copper protein (plastocyanin). Hence, the current investigation provides a new avenue to design more potent organosilane analogs.

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New selective “on-off” fluorescence chemosensor based on carbazole Schiff base for Fe3+ detection

Yin

Wang

2018

Chem Heterocycl Comp

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A new thio-Schiff base fluorophore with copper ion sensing, DNA binding and nuclease activity

Cited by 14 publications

References 40 publications

New anticancer zinc(II) complexes comprising thiosemicarbazones of saturated ring: structure, DNA/protein binding, DNA cleavage, topoisomerase‐1 inhibition and anti‐proliferation studies

New anticancer zinc(II) complexes comprising thiosemicarbazones of saturated ring: structure, DNA/protein binding, DNA cleavage, topoisomerase‐1 inhibition and anti‐proliferation studies

Intriguing interactions of triazolyl organosilane with copper (II) ion, blue copper protein, and silica nanoparticles: Spectral and theoretical approach

New selective “on-off” fluorescence chemosensor based on carbazole Schiff base for Fe3+ detection

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