A new triterpenoid saponin fromSanguisorba officinalis

Abstract

A new 19-oxo-18,19-seco-ursane-type triterpenoid saponin, named sanguisoside A (1), along with nine known triterpenoid saponins (2-10), was isolated from the roots of Sanguisorba officinalis. Their structures were determined on the basis of spectroscopic analysis and chemical method. Compounds 2 and 3 showed cytotoxic activity against SGC-7901, SMMC-7721, A549, and DU145 cell lines.

Lipopolysaccharide-Induced Nitric Oxide and Prolyl Oligopeptidase – Inhibitory Activities of Triterpenoids from Sanguisorba officinalis

“…The dried roots of Sanguisorba officinalis L. (Rosaceae) are used in traditional Chinese medicine for the treatment of disorders such as bleeding, burns, ulcerative colitis, and chronic intestinal infections, due to their hemostatic, anti-infective, antibacterial, and anti-inflammatory activities [1][2][3][4][5][6][7][8]. Previous chemical investigations of S. officinalis revealed the existence of triterpenes, triterpenoids, saponins and polyphenols [3][4][5][6]. Moreover, S. officinalis and its active component (catechin) have been reported to possess potential neuroprotective effects and antioxidant activities [3][4][5][6][7][8].…”

“…Previous chemical investigations of S. officinalis revealed the existence of triterpenes, triterpenoids, saponins and polyphenols [3][4][5][6]. Moreover, S. officinalis and its active component (catechin) have been reported to possess potential neuroprotective effects and antioxidant activities [3][4][5][6][7][8]. Our interest in the constituents possibly responsible for these beneficial properties inspired us to undertake a further biological investigation of S. officinalis.…”