A new type of specific interneuron in the monkey hippocampus forming synapses exclusively with the axon initial segments of pyramidal cells

Somogyi, Péter; Nunzi, Maria Grazia; Gorio, Alfredo; Smith, A.D.

doi:10.1016/0006-8993(83)91076-4

Cited by 255 publications

(122 citation statements)

References 30 publications

Supporting

Mentioning

112

Contrasting

Order By: Relevance

“…These results, when compared with recent studies on the receptive fields of other cortical neurons (Moore and Nelson, 1998;Zhu and Connors, 1999;Stern et al, 2001;Brecht and Sakmann, 2002;Brecht et al, 2003;Zhu and Zhu, 2004), suggest that chandelier cells integrate excitatory and inhibitory inputs over a larger area than other cortical neurons. Given that the axo-axonic synapses that chandelier cells form on pyramidal neurons are uniquely designed (Somogyi et al, 1983;Li et al, 1992) and the excitation of chandelier cells is powerful in preventing action potential initiation at the axonal initial segment of pyramidal neurons (Buhl et al, 1994;Miles et al, 1996), these results support the speculation that chandelier cells function to monitor the overall excitability in the cortex and only fire action potentials to dampen excessive excitation.…”

Section: Whisker-evoked Responses In Fast-spiking Nonpyramidal Neuronssupporting

confidence: 57%

“…Chandelier cells are a unique type of inhibitory neuron that synapses on the axonal initial segment of pyramidal neurons (Szentagothai and Arbib, 1974;Somogyi et al, 1983;Li et al, 1992). Because loss of chandelier cells is commonly and preferentially found at epileptic foci, it is proposed that they are functionally associated with epilepsy (Williams et al, 1977;Ribak, 1985;Freund and Buzsaki, 1988;Marco et al, 1996;Arellano et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Chandelier Cells Control Excessive Cortical Excitation: Characteristics of Whisker-Evoked Synaptic Responses of Layer 2/3 Nonpyramidal and Pyramidal Neurons

Zhu¹,

Stornetta²,

Zhu³

2004

J. Neurosci.

119

116

View full text Add to dashboard Cite

Section: Whisker-evoked Responses In Fast-spiking Nonpyramidal Neuronssupporting

confidence: 57%

Section: Introductionmentioning

confidence: 99%

Chandelier Cells Control Excessive Cortical Excitation: Characteristics of Whisker-Evoked Synaptic Responses of Layer 2/3 Nonpyramidal and Pyramidal Neurons

Zhu¹,

Stornetta²,

Zhu³

2004

J. Neurosci.

119

116

View full text Add to dashboard Cite

“…These interneurons are presumably Schaffer collaterals associated cholecystokinin-positive (CCK + ) cells which innervate pyramidal cells and other classes of interneurons, as well as each other (Nunzi et al 1985;Acsady et al 1996;Gulyás et al 1996;Vida et al 1998;Somogyi and Klausberger 2005 (Somogyi et al 1983;Li et al 1992;Kiss et al 1996. In addition, the presently described small sink-source pair at the pyramidal cell level in the RE/EC CSD (see Fig.…”

Section: Discussionmentioning

confidence: 95%

Interaction of nucleus reuniens and entorhinal cortex projections in hippocampal field CA1 of the rat

Weel

Silva

2016

Brain Struct Funct

View full text Add to dashboard Cite

The nucleus reuniens (RE) and entorhinal cortex (EC) provide monosynaptic excitatory inputs to the apical dendrites of pyramidal cells and to interneurons with dendrites in stratum lacunosum-moleculare (LM) of hippocampal field CA1. However, whether the RE and EC inputs interact at the cellular level is unknown. In this electrophysiological in vivo study, low frequency stimulation was used to selectively activate each projection at its origin; field excitatory postsynaptic potentials (fEPSPs) were recorded in CA1. We applied 1) paired pulses to RE or EC, 2) combined paired pulses to RE and EC, and 3) simultaneously paired pulses to RE/EC. The main findings are that: i) stimulation of either RE or EC evoked subthreshold fEPSPs, displaying paired pulse facilitation (PPF), ii) subthreshold fEPSPs evoked by combined stimulation did not display heterosynaptic PPF, and iii) simultaneous stimulation of RE/EC resulted in enhanced subthreshold fEPSPs in proximal LM displaying a nonlinear interaction.CSD analyses of RE/EC-evoked depth profiles revealed a nonlinear enlargement of the 'LM sink-radiatum source' configuration and the appearance of an additional small sink-source pair close to stratum pyramidale, likely reflecting (peri)somatic inhibition. The nonlinear interaction between both inputs indicates that RE and EC axons form synapses, at least partly, onto the same dendritic compartments of CA1 pyramidal cells. We propose that low frequency activation of the RE-CA1 input facilitates the entorhinal-hippocampal dialogue, and may synchronize the neocortical-hippocampal slow oscillation which is relevant for hippocampal-dependent memory consolidation.

show abstract

“…8). Basket cells have been described as interneurons with small AP half-width, high AP firing rates, low somatic input resistance, multipolar dendritic trees, and extensive local axonal arborizations (Ramó n y Cajal, 1904;Marín-Padilla, 1969;Somogyi et al, 1983;Wang et al, 2002). Group lateral 1 could be described as "large basket cells" with large multipolar dendrites and significant axonal projection to neighboring columns (Helmstaedter et al, 2008c); this group received depressing monosynaptic input from L4 (Fig.…”

Section: Comparison With Other Interneuron Classificationsmentioning

confidence: 99%

Efficient Recruitment of Layer 2/3 Interneurons by Layer 4 Input in Single Columns of Rat Somatosensory Cortex

Helmstaedter¹,

Staiger²,

Sakmann³

et al. 2008

J. Neurosci.

108

109

View full text Add to dashboard Cite

Interneurons in layers 2/3 are excited by pyramidal cells within the same layer (Reyes et al., 1998; Gupta et al., 2000), but little is known about translaminar innervation of these interneurons by spiny neurons in the main cortical input layer 4 (L4). Here, we investigated (1) how efficiently L4 spiny neurons excite L2/3 interneurons via monosynaptic connections, (2) whether glutamate release from axon terminals of L4 spiny neurons depends on the identity of the postsynaptic interneuron, and (3) how L4-to-L2/3 interneuron connections compare with L4-to-L2/3 pyramidal neuron connections. We recorded from pairs of L4 spiny neurons and L2/3 interneurons in acute slices of rat barrel cortex of postnatal day 20 (P20) to P29 rats. The L4-to-L2/3 interneuron connections had an average unitary EPSP of 1.2 Ϯ 1.1 mV. We found an average of 2.3 Ϯ 0.8 contacts per connection, and the L4-to-L2/3 interneuron innervation domains were mostly column restricted. Unitary EPSP amplitudes and paired-pulse ratios in the L4-to-L2/3 interneuron connections depended on the "group" of the postsynaptic interneuron. Averaged over all L4-to-L2/3 interneuron connections, unitary EPSP amplitudes were 1.8-fold higher than in the translaminar L4-to-L2/3 pyramidal cell connections. Our results suggest that L4 spiny neurons may more efficiently recruit L2/3 interneurons than L2/3 pyramidal neurons, and that glutamate release from translaminar boutons of L4 spiny neuron axons is target cell specific.

show abstract

A new type of specific interneuron in the monkey hippocampus forming synapses exclusively with the axon initial segments of pyramidal cells

Cited by 255 publications

References 30 publications

Chandelier Cells Control Excessive Cortical Excitation: Characteristics of Whisker-Evoked Synaptic Responses of Layer 2/3 Nonpyramidal and Pyramidal Neurons

Chandelier Cells Control Excessive Cortical Excitation: Characteristics of Whisker-Evoked Synaptic Responses of Layer 2/3 Nonpyramidal and Pyramidal Neurons

Interaction of nucleus reuniens and entorhinal cortex projections in hippocampal field CA1 of the rat

Efficient Recruitment of Layer 2/3 Interneurons by Layer 4 Input in Single Columns of Rat Somatosensory Cortex

Contact Info

Product

Resources

About