A new ursane triterpenoic acid and other potential anti-inflammatory and anti-arthritic constituents from EtOAc extracts of Vitellaria paradoxa stem bark

Triterpenoids

“…294 The related lactone 650 also occurs in Ilex latifolia. from Vitellaria paradoxa, 295 the enone 657 from Codium dwarkense, 296 2b,3b,19a,23-tetrahydroxy-12-ursen-28-oic acid 658 and its glycosyl ester from Nauclea officinalis, 297 the related compounds 659, 660 and 661 and the glucosyl ester 662 from Oenothera maritima 298 and the 27,28-dioic acids 663 and 664 and their 3-glucosides 665 and 666 from Crossopteryx febrifuga. 299 New ursane saponins with new genins include bodiniosides E, F and G with the genins 667, 668 and 669, respectively, from Elsholtzia bodinieri, 300 ilexpublesnin S with genin 670, with an unusual 20b conguration, from Ilex pubescens, 301 pittangretosides C 1 and L with the genins 671 and 672, respectively, from Pittosporum angustifolium 302 and vulgaside II with genin 673 from Prunella vulgaris 241 and saponins from Callicarpa kwangtungensis with genin 674, 246 Ilex cornuta with genin 675 (ref.…”

Triterpenoids from Vitellaria paradoxa Stem Barks Reduce Nitrite Levels in LPS-Stimulated Macrophages

“…Besides shea butter, the trunk and stem barks of V. paradoxa macerated in traditional alcoholic beverages are widely used in traditional medicine for the treatment of pain and as an anti-inflammatory remedy to treat rheumatism, gastric problems, diarrhoea, and dysentery [ 1 ]. The methanolic stem bark extract showed significant anti-inflammatory and anti-arthritic effects in carrageenan-induced inflammation and CFA-induced arthritic animal models [ 3 ], and the stem bark ethyl acetate extract was also demonstrated to exert significant anti-inflammatory effects on adjuvant-induced arthritis with the alleviation of paw edema and hematological disorder associated with this condition [ 4 ]. Different studies have demonstrated that the anti-inflammatory activity of stem bark extracts is mainly ascribed to their rich triterpenoid composition [ 4 ], which have been proposed to act by inhibiting pro-inflammatory cytokines and iNOS and COX-2 expression [ 5 ].…”

“…The methanolic stem bark extract showed significant anti-inflammatory and anti-arthritic effects in carrageenan-induced inflammation and CFA-induced arthritic animal models [ 3 ], and the stem bark ethyl acetate extract was also demonstrated to exert significant anti-inflammatory effects on adjuvant-induced arthritis with the alleviation of paw edema and hematological disorder associated with this condition [ 4 ]. Different studies have demonstrated that the anti-inflammatory activity of stem bark extracts is mainly ascribed to their rich triterpenoid composition [ 4 ], which have been proposed to act by inhibiting pro-inflammatory cytokines and iNOS and COX-2 expression [ 5 ]. Recently, a V. paradoxa triterpene-rich extract was shown to suppress pro-inflammatory mediators and attenuate the cartilage degradation and pain in osteoarthritis in an obesity rat model [ 6 ].…”

Antidiarrheal activity of some selected Nigerian plants used in traditional medicine

“…[21] Pharmacological evaluation carried out on this plant include antimicrobial, [22] antidiarrheal, [23] anti-inflammatory, and anti-arthritic activities. [24] In a qualitative phytochemical analysis of the ethanolic extract of the stem bark, carbohydrates, alkaloids, saponins, tannins, and cardiac glycosides were present. [19] Senna surattensis (Burm.…”