A new variant of Creutzfeldt-Jakob disease in the UK

Will, Robert; Ironside, James W.; Zeidler, Martin; Cousens, Simon; Estibeiro, K; Alpérovitch, Annick; Poser, S.; Pocchiari, Maurizio; Hofman, Albert; Smith, P. G.

doi:10.1016/s0140-6736(96)91412-9

Cited by 2,417 publications

(1,355 citation statements)

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“…The large extent of the epidemic during the nineteen-nineties in the United Kingdom, as well as the fact that it was observed progressively in several other countries, have pushed the authorities and researchers to look more closely at the disease. BSE really * Corresponding author: n.jarrige@lyon.afssa.fr became a subject of major interest when a causal link between BSE and a variant of Creutzfeldt-Jakob disease (vCJD) in Humans was evidenced in 1996 [8,12,24].…”

Section: Introductionmentioning

confidence: 99%

Case-control study on feed risk factors for BSE cases born after the feed ban in France

Jarrige¹,

Ducrot²,

Cazeau³

et al. 2007

Vet. Res.

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-In France, after the ban on meat and bone meal (MBM) in cattle feeding in June 1990, cases of Bovine Spongiform Encephalopathy (BSE) have continued to be detected in bovines born after that ban (called BAB cases). A case-control study was therefore carried out to determine the way these cases were contaminated. A multivariate conditional model was built adjusting for the production type of the animals and taking into account the herd size. The results confirmed that feeding cattle with proprietary concentrates was at risk for BSE, with an adjusted odds ratio of 6.8 (2.5; 18.7) for the consumption of less or three different proprietary concentrates and 17.6 (5.7; 54.8) for more than three, when comparing with no consumption of proprietary concentrates, considering feeding of bovines before the age of two. The results suggest that cross-contaminations by MBM in bovine concentrates have occurred after 1990. To a lesser extent, on-farm cross-contaminations, i.e. consumption by cattle of feedstuffs initially dedicated to other animals and which could legally contain MBM, have probably also existed, since the presence on farms of poultry fed purchased feed involved an increased risk of BSE with an odds ratio of 1.8 (1.1; 3.0). The use of milk replacers, which often incorporates animal fats, was also at risk with an odds ratio of 1.8 (1.0; 3.1).BSE / cross-contamination / cattle feeding / proprietary concentrates / France

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Section: Introductionmentioning

confidence: 99%

Case-control study on feed risk factors for BSE cases born after the feed ban in France

Jarrige¹,

Ducrot²,

Cazeau³

et al. 2007

Vet. Res.

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“…[16,17] Distinguishing between different prion strains rapidly is therefore desirable. Various dendrimers have been shown to be capable of interfering with the aggregation of amyloid fibrillar structures associated with Alzheimer's and prion diseases.…”

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confidence: 99%

Differentiating Prion Strains Using Dendrimers

McCarthy

Rasines

Appelhans

et al. 2012

Adv Healthcare Materials

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“…37 Beginning in 1993, a new clinical syndrome reminiscent of CJD was identified among young people in Britain. 12 This syndrome was later named vCJD, and is characterized by prominent behavioral features, ataxia, dementia, and ultimately death. The age of onset of vCJD is much younger than classical CJD, typically affecting those in their teens and 20s.…”

Section: The Science Of Bsementioning

confidence: 99%

“…The developing scientific narrative surrounding BSE and vCJD was captured in leading medical journals of the 1990s, serving both as a historical chronicle and locus of debate. 12,13 The British BSE experience has been historically contextualized, most notably in the work of acclaimed veterinary historian Abigail Woods. 14,15 Contemporary policy analysis has focused largely on the concept of risk: its assessment, management, and communication.…”

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confidence: 99%

The Canadian Management of Bovine Spongiform Encephalopathy in Historical and Scientific Perspective, 1990-2014

Quimby

Shamy

2015

Can. J. Neurol. Sci.

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On February 11, 2015, the Canadian Food Inspection Agency announced that a cow born and raised in Alberta had tested positive for bovine spongiform encephalopathy (BSE), commonly known as mad cow disease. BSE is a prion disease of cattle that, when transmitted to humans, produces a fatal neurodegenerative disease known as variant Creutzfeldt-Jakob disease. We believe that this latest case of BSE in Canadian cattle suggests the timeliness of a review of the management of BSE in Canada from a historically and scientifically informed perspective. In this article, we ask: how did the Canadian management of BSE between 1990 and 2014 engage with the contemporary understanding of BSE’s human health implications? We propose that Canadian policies largely ignored the implicit medical nature of BSE, treating it as a purely agricultural and veterinary issue. In this way, policies to protect Canadians were often delayed and incomplete, in a manner disturbingly reminiscent of Britain’s failed management of BSE. Despite assurances to the contrary, it is premature to conclude that BSE (and with it the risk of variant Creutzfeldt-Jakob disease) is a thing of Canada’s past: BSE remains very much an issue in Canada’s present.

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A new variant of Creutzfeldt-Jakob disease in the UK

Cited by 2,417 publications

References 16 publications

Case-control study on feed risk factors for BSE cases born after the feed ban in France

Case-control study on feed risk factors for BSE cases born after the feed ban in France

Differentiating Prion Strains Using Dendrimers

The Canadian Management of Bovine Spongiform Encephalopathy in Historical and Scientific Perspective, 1990-2014

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