A New Vasodilatikg and Antispasmodic Agent: Isoxsuprine Hydrochloride

Isoxsuprine in the Treatment of Sickle Cell Painful Crises: A Double-Blind Comparative Study with Narcotic Analgesic

“…It improves red cell deformability, decreases adhesion of the platelets to damaged vessel walls, 16,17 decreases blood viscosity, 18,19 dilates deep peripheral vessels, and stimulates the myocardium. [20][21][22] The drug may exert other actions at the cellular or molecular level, such as the effects on polymorphonuclear leukocytes and inflammatory mediators. Further studies in this regard are needed.…”

Isoxsuprine Hydrochloride in Cold Injury

“…The administration of isoxsuprine hydrochloride causes an increase in caliber of both normal and decreased blood vessels by its indirect effect on smooth muscles with a selective action on the blood vessels (17). The increased radioactive-iodine clearance after intramuscular injection of isox- suprine hydrochloride suggests that nutritional flow through the capillaries is increased (18).…”

Report of Scottish General Practitioner Open Multicentre Study of Isoxsuprine (Duvadilan Retard) in the Management of Intermittent Claudication

“…Many studies have demonstrated the efficacy of isoxsuprine in PVD 2–13 . During the trial, the currently available retard preparation of isoxsuprine in a compliance pack was used.…”