A New Versatile Synthesis of Functionalized Phosphine Oxides—Efficient Ligands for Rare-Earth Metals Extraction

An efficient direct phosphinylation and alkylation of ketones to construct C–P and C–C bonds: access to α,α-disubstituted γ-ketophosphine oxides

“…8 Moreover, 4-(diethylphosphoryl)-4-methylpentan-2-one, one of the first γ-ketophosphine oxide drug precursors, has demonstrated high anticholinesterase activity upon further transformation (Scheme 2). 9 However, the synthesis of the anticholinesterase skeleton required multiple steps or complex available substrates in previous reports, 10 and our strategy can be performed in only one step with easily available substrates of ketones (Scheme 2). As a result of the interest in the biological activity of γ-ketophosphine oxides, intense research has been conducted on synthesis strategies for the preparation of this structural motif.…”

Design of Extractants for F-Block Elements in a Series of (2-(Diphenylphosphoryl)methoxyphenyl)diphenylphosphine Oxide Derivatives: Synthesis, Quantum-Chemical, and Extraction Studies

“…Moreover, an advantage of phosphoryl podands is the possibility to change the coordination properties of the phosphoryl group in a wide range by varying substituents at the phosphorus atom [13,14]. Furthermore, the methods of organophosphorus chemistry allow constructing a wide range of phosphoryl-containing podands of different conformational rigidities and diverse number of coordination centers, which opens wide possibilities for the targeted modification of their extraction properties [15][16][17][18]. A systematic study of the extraction properties of polydentate organic compounds is necessary to find new efficient extractants for elements important for the industry [19,20].…”