A new version of hydrophilic interaction liquid chromatography with the use of ionic liquids based on imidazole for the determination of highly polar drugs in body fluids

Somova, V. D.; Бессонова, Е. А.; Карцова, Л. А.

doi:10.15826/analitika.2017.21.3.004

Cited by 1 publication

(2 citation statements)

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“…In addition, the use of ILs is also possible in hydrophilic interaction liquid chromatography (HILIC). The increase in the stationary phase surface polarity obtained after the addition of an IL is responsible for improving the retention and efficiency parameters [146]. The verification of the positive effect of ILs was also presented in studies focusing more on the kind of columns used.…”

Section: Il Additives To the Mobile Phasementioning

confidence: 90%

“…However, considering the topic of ILs in drug determination, it should be highlighted that these works mainly focus on explaining the function of ILs in the suppression process and the drugs are less important as analytes. In addition, only a few works use biological [140,141,[144][145][146] or environmental [142] samples as the matrices; in one, tablets were analyzed [147], but most often they were aqueous solutions [6,143,[147][148][149][150][151][152][153][154]. Focusing on the addition of an IL to the mobile phase in LC, it should be noted that the interpretation of the results requires consideration of the influence of both the IL anion and cation.…”

Section: Il Additives To the Mobile Phasementioning

confidence: 99%

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The Influence of Ionic Liquids on the Effectiveness of Analytical Methods Used in the Monitoring of Human and Veterinary Pharmaceuticals in Biological and Environmental Samples—Trends and Perspectives

et al. 2020

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Recent years have seen the increased utilization of ionic liquids (ILs) in the development and optimization of analytical methods. Their unique and eco-friendly properties and the ability to modify their structure allows them to be useful both at the sample preparation stage and at the separation stage of the analytes. The use of ILs for the analysis of pharmaceuticals seems particularly interesting because of their systematic delivery to the environment. Nowadays, they are commonly detected in many countries at very low concentration levels. However, due to their specific physiological activity, pharmaceuticals are responsible for bioaccumulation and toxic effects in aquatic and terrestrial ecosystems as well as possibly upsetting the body’s equilibrium, leading to the dangerous phenomenon of drug resistance. This review will provide a comprehensive summary of the use of ILs in various sample preparation procedures and separation methods for the determination of pharmaceuticals in environmental and biological matrices based on liquid-based chromatography (LC, SFC, TLC), gas chromatography (GC) and electromigration techniques (e.g., capillary electrophoresis (CE)). Moreover, the advantages and disadvantages of ILs, which can appear during extraction and separation, will be presented and attention will be given to the criteria to be followed during the selection of ILs for specific applications.

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Section: Il Additives To the Mobile Phasementioning

confidence: 90%