2002
DOI: 10.1080/00015458.2002.11679261
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A Newly Designed Vertebral Replacement Implant to Reconstruct the Thoracolumbar Spine Anteriorly

Abstract: Calcium phosphate compounds are becoming of increasingly great importance in the field of biomaterials and, in particular, as bone substitutes. In this way donor-side morbidity can be avoided. A type A lesion of the vertebral body can be the reason of a neurological deficit, requiring a corpectomy by means of an anterior approach, tricortical bone grafting and internal stabilization to get a fusion over time. It is our aim to introduce in this study a newly designed vertebral replacement device, tested in an a… Show more

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Cited by 4 publications
(6 citation statements)
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“…In this way, donor tissue-induced morbidity can be avoided. (6) Today, calcium-phosphate cements are placed routinely in alveolar bone following tooth extraction prior to tooth implant (9) and are being developed for augmentation of fractures in the extremities as well as for vertebral compressive fractures in the spine. (10) We therefore asked whether a calciumphosphate cement placed in the ablated marrow cavity could affect the new bone formed and possibly extend its half-life.…”
Section: Resultsmentioning
confidence: 99%
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“…In this way, donor tissue-induced morbidity can be avoided. (6) Today, calcium-phosphate cements are placed routinely in alveolar bone following tooth extraction prior to tooth implant (9) and are being developed for augmentation of fractures in the extremities as well as for vertebral compressive fractures in the spine. (10) We therefore asked whether a calciumphosphate cement placed in the ablated marrow cavity could affect the new bone formed and possibly extend its half-life.…”
Section: Resultsmentioning
confidence: 99%
“…We also ask whether molecules that inhibit osteoclasts, such as bisphosphonates, can protect the new bone formed 3 weeks after mechanical ablation of the marrow and treatment with PTH. Furthermore, we ask whether the implantation of bone-formation-promoting calcium-phosphate cements (6) inside the ablated marrow cavity can provide a scaffold for the maintenance of the newly formed bone and whether PTH treatment following such cement implantation synergistically modifies that new bone.…”
Section: Introductionmentioning
confidence: 99%
“…2 In a study in which Biobon was used as bone filler in a vertebroplasty, the initial defect was only partially filled with dense bone. 18 An area of connective tissue covered a substantial area in the vertebral body, and the degradation rate of the synthetic bone substitute seemed faster compared with the ingrowth of bone tissue. 18 In our opinion, Biobon was not suitable to use in combination with cancellous bone grafts in our critically sized animal model.…”
Section: Discussionmentioning
confidence: 99%
“…It is well known for its biocompatibility with bone tissue and its osteoconductive properties. 2,4,5,10,13,18 The cement functions as a temporary scaffold to support new bone formation. Ideally, after implantation, the cement is slowly resorbed and remodeled, after which the original bone architecture can be restored.…”
Section: Discussionmentioning
confidence: 99%
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