A Newly Developed Electrochemical Method for the Simultaneous Determination of Camylofin and Analgine in Pharmaceutical Preparation and Biological Fluids

Abstract

A simple, rapid and highly sensitive electrochemical sensing platform has been developed for the simultaneous determination of Camylofin (CAM) and Analgine (ANG). The electrochemical oxidation based on bare and bulk zinc oxide nanoparticles (ZnO/NPs) and ionic liquid (IL) modified carbon paste electrode (ZnO/IL/MCPE) have been studied using cyclic voltammetry and square-wave voltammetric techniques. Under optimum conditions, the linearity range was from 1 μmol L −1 to 100 μmol L −1 and 0.2 μmol L −1 to 100 μmol L −1 for ANG and CAM, at bare and at ZnO/IL/MCPE, respectively in pH 7. The ZnO/IL/MCPE sensor was then explored toward the analysis of ANG and CAM in pharmaceutical formulation, real human serum and urine with excellent recoveries. The obtained results were compared successfully with respect to those obtained using the reported method. Moreover, this sensor is sensitive for the determination of ANG and CAM in the presence of common interference molecules uric acid (UA) and ascorbic acid (AA). The fabricated ZnO/IL/MCPE was demonstrated to exhibit a high sensitivity, good stability toward the sensing of ANG and CAM and was successfully used as a clinical assay and in quality assurance of pharmaceutical products.

Nano Green Voltammetric Determination of Imidocarb Dipropionate and Its Residues in Bovine Meat, Milk and Urine Samples

“…The electrooxidation related to proton exchange in buffer solution. [26][27][28] Optimization of experimental conditions.-Effect of pH.-The effect of pH is well known to have a prime impact on the response of organic and inorganic drug compounds. 29 This parameter was studied to detect the oxidation process of IMD at (bare CPE, GNP/MWCNT) in pH range 2 to 10 using B-R buffer.…”

“…4a) is the response of peak current as a function of pH where it is observed that pH 4 BR buffer provides the highest anodic current. 26 Effect of scan rate.-The interfacial reaction of IMD at each electrode was identified by recording the cyclic voltammograms of 1 × 10 -5 mol l −1 solution at different scan rates (υ)20-150 mV s −1 in B-R buffer (pH 4.0) for bare CPE, GNP/MWCNT.…”

Review—Point-of-Care Urinalysis with Emerging Sensing and Imaging Technologies

“…69,70 Ionic liquid modified carbon paste electrodes with ZnO nanoparticles have been used to simultaneously detect the drugs Analgine and Camylofin. 71 Multiwalled carbon nanotube (MWCNT) structures with Zinc nanoparticles have been used for the simultaneous detection of two antidepressant 41 The aggregation of target antigens is monitored by the development of color and magnetic field. drugs.…”

Analytical Eco-Scale for Evaluating the Uniqueness of Voltammetric Method used for Determination of Antiemetic Binary Mixture Containing Doxylamine Succinate in Presence of its Toxic Metabolite

“…It has been used in a variety of applications, including sensing and catalysis [38]. The modified carbon paste electrode (MCPE) was found to be superior to the unmodified one because the unmodified electrode has some drawbacks such as slow electron transfer, low sensitivity, and reproducibility [39]. Nanomaterials, transition metal compounds, and multi-walled carbon nanotubes (MWCNT) are used to resolve these drawbacks.…”