A newly developed oral infection mouse model of shigellosis for immunogenicity and protective efficacy studies of a candidate vaccine
Risha Haldar,
Prolay Halder,
Hemanta Koley
et al.
Abstract:Shigella
infection poses a significant public health challenge in the developing world. However, lack of a widely available mouse model that replicates human shigellosis creates a major bottleneck to better understanding of disease pathogenesis and development of newer drugs and vaccines. BALB/c mice pre-treated with streptomycin and iron (FeCl
3
) plus desferrioxamine intraperitoneally followed by oral infection with virulent
Shigella flexneri 2a
… Show more
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