A newly discovered stem cell that keeps bones growing

Wuelling, Manuela; Vortkamp, Andrea

doi:10.1038/d41586-019-00527-w

Cited by 14 publications

(9 citation statements)

References 8 publications

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“…The same stem cells are also able to transdifferentiate to long‐lived stem cells of the bone‐marrow stroma. This cell population in the growth plate may be essential for postnatal skeletal growth, and may represent a “fountain of bone growth” (Wuelling & Vortkamp, 2019). These findings raise the yet untested hypothesis that perhaps a cartilage‐bone stem cell population may have been depleted or otherwise damaged in children, such as those described in this series, because of one or a combination of factors, such as hyperinflammation, auto‐immunity, HSCT conditioning, or GvHD.…”

Section: Discussionmentioning

confidence: 99%

Chondrodysplasia and growth failure in children after early hematopoietic stem cell transplantation for non‐oncologic disorders

Botto

Meeths

Campos‐Xavier

et al. 2021

American J of Med Genetics Pt A

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Bone dysplasias (osteochondrodysplasias) are a large group of conditions associated with short stature, skeletal disproportion, and radiographic abnormalities of skeletal elements. Nearly all are genetic in origin. We report a series of seven children with similar findings of chondrodysplasia and growth failure following early hematopoietic stem cell transplantation (HSCT) for pediatric non-oncologic disease: hemophagocytic lymphohistiocytosis or HLH (five children, three with biallelic HLH-associated

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Section: Discussionmentioning

confidence: 99%

Chondrodysplasia and growth failure in children after early hematopoietic stem cell transplantation for non‐oncologic disorders

Botto

Meeths

Campos‐Xavier

et al. 2021

American J of Med Genetics Pt A

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“…Bone, with its hierarchical structure and precise inorganic–organic interface, is a dynamic tissue that constantly undergoes self‐repair to maintain its load‐bearing characteristics . However, the bone remodeling process cannot adequately compensate for the destruction caused in certain cases, such as large bone fractures and defects, which require additional surgical intervention for fixing ruptured tissues and facilitating healing .…”

Section: Introductionmentioning

confidence: 99%

Bioinspired Mineral–Organic Bone Adhesives for Stable Fracture Fixation and Accelerated Bone Regeneration

Bai

Zhang

et al. 2019

Adv Funct Materials

161

147

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The use of hydrogel-based bone adhesives has the potential to revolutionize the clinical treatment of bone repairs. However, severe deficiencies remain in current products, including cytotoxicity concerns, inappropriate mechanical strength, and poor fixation performance in wet biological environments. Inspired by the unique roles of glue molecules in the robust mechanical strength and fracture resistance of bone, a design strategy is proposed using novel mineral-organic bone adhesives for strong water-resistant fixation and guided bone tissue regeneration. The system leveraged tannic acid (TA) as a phenolic glue molecule to spontaneously co-assemble with silk fibroin (SF) and hydroxyapatite (HA) in order to fabricate the inorganic-organic hybrid hydrogel (named SF@TA@HA). The combination of the strong affinity between SF and TA along with sacrificial coordination bonds between TA and HA significantly improves the toughness and adhesion strength of the hydrogel by increasing the amount of energy dissipation at the nanoscale. This in turn facilitated adequate and stable fixation of bone fracture in wet biological environments. Furthermore, SF@TA@HA promotes the regeneration of bone defects at an early stage in vivo. This work presents a type of bioinspired bone adhesive that is able to provide stable fracture fixation and accelerated bone regeneration during the bone remodeling process.

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“…Our data indicate that SDC3's regulatory role extends into adulthood as SDC3 deletion leads at 3 months of age to a thin growth plate with disorganised columns of chondrocytes within the proliferating zone, which is associated with mild, but significant long bone growth stunting compared to the reverse seen in utero. This growth plate abnormality may be due to defective chondrogenesis at stem cell level in the growth plate resting zone 46,47 , and/or at the proliferation and differentiation stages of chondrocytes 19,20 , in which extracellular matrix, with which transmembrane HSPGs interact, is thought to play a role. Further investigations are in progress to assess the exact role of SDC3 in the regulation of chondrocytes within the growth plate and in longitudinal bone growth.…”

Section: Discussionmentioning

confidence: 99%

Syndecan-3 enhances anabolic bone formation through WNT signalling

Brito

Butcher

Pisconti

et al. 2019

Preprint

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Osteoporosis is the most common age-related metabolic bone disorder, which is characterised by low bone mass and deterioration in bone architecture, with a propensity to fragility fractures. The best treatment for osteoporosis relies on stimulation of osteoblasts to form new bone and restore bone structure, however anabolic therapeutics are few and their use is timerestricted. Here we report that Syndecan-3 (SDC3) increases new bone formation through enhancement of WNT signalling. Young adult Sdc3 -/mice have a low bone volume phenotype associated with reduced bone formation, increased bone marrow adipose tissue (BMAT), increased bone fragility and a blunted anabolic bone formation response to mechanical loading. The premature osteoporosis-like phenotype of Sdc3 -/mice is primarily explained by delayed osteoblast maturation and impaired osteoblast function, with contributing increased osteoclast-mediated bone resorption. Mechanistically, SDC3 enhances canonical WNT signalling in osteoblasts through stabilisation of Frizzled 1, making SDC3 an attractive target for novel anabolic drug development. KEY WORDS Syndecan-3, bone, osteoblast, osteoclast, WNT, Frizzled

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A newly discovered stem cell that keeps bones growing

Cited by 14 publications

References 8 publications

Chondrodysplasia and growth failure in children after early hematopoietic stem cell transplantation for non‐oncologic disorders

Chondrodysplasia and growth failure in children after early hematopoietic stem cell transplantation for non‐oncologic disorders

Bioinspired Mineral–Organic Bone Adhesives for Stable Fracture Fixation and Accelerated Bone Regeneration

Syndecan-3 enhances anabolic bone formation through WNT signalling

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