A next-generation probiotic: Akkermansia muciniphila ameliorates chronic stress–induced depressive-like behavior in mice by regulating gut microbiota and metabolites

Ding, Yang; Bu, Fan; Chen, Tuo; Shi, Guo‐Ping; Yuan, Xiaomin; Feng, Zeyu; Duan, Zhenglan; Wang, Rong; Zhang, Sumin; Wang, Qiong; Zhou, Jin‐Yong; Chen, Yugen

doi:10.1007/s00253-021-11622-2

Cited by 107 publications

(81 citation statements)

References 68 publications

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“…In addition to these factors, the gut microbiome has been reported to play an important role in controlling the BDNF level of the host. Since Sudo et al showed that hippocampal BDNF levels decreased in germ-free mice compared with SPF mice [10], the relationship between BDNF and the gut microbiota has been investigated in numerous studies, using germ-free, antibiotic-treated, depression model, and fecal microbiota-transplanted mice [43][44][45][46][47], while impaired hippocampal neurogenesis has been reported in germ-free mice [48]. As an increase in the BDNF level correlates with an improvement in depressive symptoms [35,36], modulation of the gut microbiome, to increase the brain BDNF level and neurogenesis, may lead to an improvement in the symptoms.…”

Section: Decreased Neurogenesis and Its Association With Bdnfmentioning

confidence: 99%

How Microbes Affect Depression: Underlying Mechanisms via the Gut–Brain Axis and the Modulating Role of Probiotics

Suda

Matsuda

2022

IJMS

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Accumulating evidence suggests that the gut microbiome influences the brain functions and psychological state of its host via the gut–brain axis, and gut dysbiosis has been linked to several mental illnesses, including major depressive disorder (MDD). Animal experiments have shown that a depletion of the gut microbiota leads to behavioral changes, and is associated with pathological changes, including abnormal stress response and impaired adult neurogenesis. Short-chain fatty acids such as butyrate are known to contribute to the up-regulation of brain-derived neurotrophic factor (BDNF), and gut dysbiosis causes decreased levels of BDNF, which could affect neuronal development and synaptic plasticity. Increased gut permeability causes an influx of gut microbial components such as lipopolysaccharides, and the resultant systemic inflammation may lead to neuroinflammation in the central nervous system. In light of the fact that gut microbial factors contribute to the initiation and exacerbation of depressive symptoms, this review summarizes the current understanding of the molecular mechanisms involved in MDD onset, and discusses the therapeutic potential of probiotics, including butyrate-producing bacteria, which can mediate the microbiota–gut–brain axis.

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Section: Decreased Neurogenesis and Its Association With Bdnfmentioning

confidence: 99%

How Microbes Affect Depression: Underlying Mechanisms via the Gut–Brain Axis and the Modulating Role of Probiotics

Suda

Matsuda

2022

IJMS

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“…In other studies, isolated cases of mild adverse events were reported. The first studies assessing the effect of probiotics on the alleviation of depression were presented in a mouse model [ 77 , 78 , 79 , 80 ] and a rat model [ 81 , 82 , 83 , 84 ], using one bacterial strain [ 79 , 81 ]. Animal model studies have produced promising results.…”

Section: Resultsmentioning

confidence: 99%

“…Animal model studies have produced promising results. For example, Ding et al [ 78 ] showed that Akkermansia muciniphila supplementation alleviated the symptoms of depression in mice through a mechanism related to the regulation of metabolites and the gut microbiota. In turn, Birmann et al [ 80 ] showed that Komagataella pastoris KM71H supplementation in mice prevented depression-like behavior.…”

Section: Resultsmentioning

confidence: 99%

The Role of Psychobiotics in Supporting the Treatment of Disturbances in the Functioning of the Nervous System—A Systematic Review

Skowron

Budzyńska

Wiktorczyk-Kapischke

et al. 2022

IJMS

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Stress and anxiety are common phenomena that contribute to many nervous system dysfunctions. More and more research has been focusing on the importance of the gut–brain axis in the course and treatment of many diseases, including nervous system disorders. This review aims to present current knowledge on the influence of psychobiotics on the gut–brain axis based on selected diseases, i.e., Alzheimer’s disease, Parkinson’s disease, depression, and autism spectrum disorders. Analyses of the available research results have shown that selected probiotic bacteria affect the gut–brain axis in healthy people and people with selected diseases. Furthermore, supplementation with probiotic bacteria can decrease depressive symptoms. There is no doubt that proper supplementation improves the well-being of patients. Therefore, it can be concluded that the intestinal microbiota play a relevant role in disorders of the nervous system. The microbiota–gut–brain axis may represent a new target in the prevention and treatment of neuropsychiatric disorders. However, this topic needs more research. Such research could help find effective treatments via the modulation of the intestinal microbiome.

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“…abundances may play a role in the pathogenesis of depression [53]. Its role in the intestinal barrier permeability and protection from intestinal inflammation has been established [54]. The primary butyric acid manufacturer, Faecalibacterium prausnitzii, exhibits a significant positive correlation with mood.…”

Section: The Composition Of Intestinal Microbiota and Its Effects On ...mentioning

confidence: 99%

The Intervention of Prebiotics on Depression via the Gut–Brain Axis

He¹,

Si²,

Sun³

et al. 2022

Molecules

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The imbalance of intestinal microbiota can cause the accumulation of endotoxin in the main circulation system of the human body, which has a great impact on human health. Increased work and life pressure have led to a rise in the number of people falling into depression, which has also reduced their quality of life. The gut–brain axis (GBA) is closely related to the pathological basis of depression, and intestinal microbiota can improve depressive symptoms through GBA. Previous studies have proven that prebiotics can modulate intestinal microbiota and thus participate in human health regulation. We reviewed the regulatory mechanism of intestinal microbiota on depression through GBA, and discussed the effects of prebiotics, including plant polysaccharides and polyphenols on the regulation of intestinal microbiota, providing new clues for the prevention and treatment of depression.

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A next-generation probiotic: Akkermansia muciniphila ameliorates chronic stress–induced depressive-like behavior in mice by regulating gut microbiota and metabolites

Cited by 107 publications

References 68 publications

How Microbes Affect Depression: Underlying Mechanisms via the Gut–Brain Axis and the Modulating Role of Probiotics

How Microbes Affect Depression: Underlying Mechanisms via the Gut–Brain Axis and the Modulating Role of Probiotics

The Role of Psychobiotics in Supporting the Treatment of Disturbances in the Functioning of the Nervous System—A Systematic Review

The Intervention of Prebiotics on Depression via the Gut–Brain Axis

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