A niche for every cell, for every function

Systemic Redox Imbalance in Chronic Kidney Disease: A Systematic Review

“…These results in HD concur with findings in predialysis patients, where also EPO appears to confer an antioxidant advantage [ 28 ], by preventing the reduction in erythrocytes GPx activity observed in patients not receiving EPO. Moreover, while erythropoiesis is, in a healthy individual, stimulated by ROS, as discussed by Migliaccio, erythropoiesis also counteracts circulating ROS levels via increases in available catalase and possibly other antioxidant enzymes [ 57 ]. Further, on the atherosclerosis mechanism, the presence of F2-isoprostanes has been determined in human atherosclerotic lesions [ 58 ].…”

A Shift in Myeloid Cell Phenotype via Down Regulation of Siglec-1 in Island Macrophages of Bone Marrow Is Associated With Decreased Late Erythroblasts Seen in Anemia of Critical Illness

“…The concept of erythroblast island macrophages (EBIMØ) has been known for more than 60 years (10) but not completely understood (11, 12). Recent in vitro evidence using time lapse video microscopy shows the interaction of macrophages with erythroblasts at various stages of maturation (13). Therefore, characterizing the phenotype of EBIMØ in burn pathology is essential to understand the efficacy of erythroblast islands contributing to the maturation of erythroblasts and to eventually underscore the intercellular signals.…”

Mechanisms of muscle function

“…EPO appears to help as Sommerburg et al (Sommerburg et al, 1998) reported that HD patients who received long-term EPO treatment presented decreased levels of lipid peroxidation. These results in HD concur with findings in pre-dialysis patients, where also EPO appears to confer an antioxidant advantage (Papavasiliou et al, 2005), by preventing the reduction in erythrocytes GPx activity observed in patients not (Migliaccio, 2013). Further on the atherosclerosis mechanism, the presence of F2isoprostanes has been determined in human atherosclerotic lesions (Pratico et al, 1997).…”