A Nile blue based infrared fluorescent probe: imaging tumors that over-express cyclooxygenase-2

Wang, Benhua; Fan, Jiangli; Wang, Tonghua; Zhu, Hao; Wang, Jingyun; Mu, Huiying; Peng, Xiaojun

doi:10.1039/c4cc08915d

Cited by 63 publications

(39 citation statements)

References 40 publications

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“…Peng et al developed two-photon activatable fluorescent probes 16-19 for imaging COX-2 in cells and in vivo. [88][89][90][91] All of these free probes existed in the folded state. This molecular configuration led to quenching of fluorescence due to photoinduced electron transfer (PET) between the fluorophores and the inhibitor of COX-2.…”

Section: Probes Integrating Tumor-targeting Ligandsmentioning

confidence: 99%

“…Probe 18 afforded high sensitivity and selectivity for COX-2 with a detection limit of 1.0 nM. 90 Probe 19 was a COX-2-specific NIR fluorescent probe 91 that could be directly applied to native polyacrylamide gel electrophoresis analysis and in-gel fluorescence analysis. This utilization facilitated rapid and sensitive screening of cancer cells without the need for a time-consuming enzymelinked immunosorbent assay (ELISA).…”

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confidence: 99%

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Fluorescent chemical probes for accurate tumor diagnosis and targeting therapy

et al. 2017

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Surgical resection of solid tumors is currently the gold standard and preferred therapeutic strategy for cancer. Chemotherapy drugs also make a significant contribution by inhibiting the rapid growth of tumor cells and these two approaches are often combined to enhance treatment efficacy. However, surgery and chemotherapy inevitably lead to severe side effects and high systemic toxicity, which in turn results in poor prognosis. Precision medicine has promoted the development of treatment modalities that are developed to specifically target and kill tumor cells. Advances in in vivo medical imaging for visualizing tumor lesions can aid diagnosis, facilitate surgical resection, investigate therapeutic efficacy, and improve prognosis. In particular, the modality of fluorescence imaging has high specificity and sensitivity and has been utilized for medical imaging. Therefore, there are great opportunities for chemists and physicians to conceive, synthesize, and exploit new chemical probes that can image tumors and release chemotherapy drugs in vivo. This review focuses on small molecular ligand-targeted fluorescent imaging probes and fluorescent theranostics, including their design strategies and applications in clinical tumor treatment. The progress in chemical probes described here suggests that fluorescence imaging is a vital and rapidly developing field for interventional surgical imaging, as well as tumor diagnosis and therapy.

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Section: Probes Integrating Tumor-targeting Ligandsmentioning

confidence: 99%

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confidence: 99%

Fluorescent chemical probes for accurate tumor diagnosis and targeting therapy

et al. 2017

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“…As discussed above, most dye‐functionalized MSNs are based on FITC which emits green fluorescence. Compared with green light (490–570 nm), near‐infrared (NIR) light (650–900 nm) is more suitable for biological applications due to several advantages such as minimum photodamage to biological samples, minimal interference from background autofluorescence, and acceptable tissues penetration . Thus, NIR dyes, for example, cyanine dyes, as fluorescent tracer modified on the surface of innorganic nanoparticles are considered as an attractive alternative choice for detection of tumor sites and optical imaging in vivo .…”

Section: Anticancer Drug Delivery Systems Based On Inorganic Nanocarrmentioning

confidence: 99%

“…Furthermore, fluorescence imaging technique with low cost, high selectivity and sensitivity, nondestruction and fast response time, has been widely used for the localization and monitoring of the drug release in vivo . Theranostic nanocarriers equipped with fluorescence tracers as optical reporters have also become attractive for real‐time monitoring of the drug delivery process, and their fluorescence signals may contribute to the evaluation of the therapeutic effects of drugs .…”

Section: Introductionmentioning

confidence: 99%

Anticancer drug delivery systems based on inorganic nanocarriers with fluorescent tracers

et al. 2017

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In recent years, anticancer nanomedicines have mainly been developed for chemotherapy and combination therapy in which the main contributing anticancer drugs are delivered by deliberately designed nano drug delivery systems (nano‐DDSs). Inorganic nanocarriers equipped with fluorescent tracers have become attractive tools to monitor the whole drug delivery and release processes. The fluorescence signal of tracers could be observed concomitantly with drug release, and thus, this strategy is of great benefit to evaluate the therapeutic effects of the nano‐DDSs. This review provides a brief overview about three inorganic nanocarriers for drug delivery, including mesoporous silica, Fe3O4, and hydroxyapatite. We mainly discussed about their preparation processes, drug loading capacities, and the development of different fluorescent materials (fluorescent dyes, quantum dots, fluorescent macromolecules, and rare earth metals) hybridized to nanocarriers for real‐time monitoring of drug release both in vitro and in vivo. This review also provides some recommendations for more in‐depth research in future. © 2017 American Institute of Chemical Engineers AIChE J, 64: 835–859, 2018

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“…26,27 Although IMC is a non-selective COX isoforms inhibitor (COX-1 and COX-2), it becomes more selective aer conjugation with uorescent dyes. 6,24,[28][29][30][31] For example, indomethacin (IMC) was linked to Nile Blue dye using a hexanediamine linker as a NIR uorescent imaging probe. 30 The probe showed Golgi localization in cancer cells that overexpressed COX-2.…”

Section: Introductionmentioning

confidence: 99%