A Nodular Protuberance on the Hard Palate

Ladizinski, Barry; Lee, Kachiu C.

doi:10.1001/jama.2014.271

Cited by 6 publications

(4 citation statements)

References 2 publications

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“…To date, the etiology of MT is still unknown. Several mechanisms have been proposed, including genetics, trauma, and dietary habits (Ladizinski and Lee 2014). Despite the most widely accepted theory of genetic etiology, torus has not always been reported as autosomal dominant (Eggen 1989; Bruce et al 2004).…”

Section: Introductionmentioning

confidence: 99%

Loss of Notch3 Signaling Enhances Osteogenesis of Mesenchymal Stem Cells from Mandibular Torus

et al. 2016

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Mandibular torus (MT) is a common intraoral osseous outgrowth located on the lingual surface of the mandible. Histologic features include hyperplastic bone consisting of mature cortical and trabecular bone. Some theories on the etiology of MT have been postulated, such as genetic factors, masticatory hyperfunction, trauma, and continued growth, but the underlying mechanism remains largely unknown. In this study, we investigated the potential role of mesenchymal stem cells (MSCs) derived from human MT in the pathogenesis of bone outgrowth. We demonstrated that MT harbored a distinct subpopulation of MSCs, with enhanced osteogenic and decreased adipogenic differentiation capacities, as compared with their counterparts from normal jaw bone. The increased osteogenic differentiation of mandibular torus MSCs was associated with the suppression of Notch3 signaling and its downstream target genes, Jag1 and Hey1, and a reciprocal increase in the transcriptional activation of ATF4 and NFATc1 genes. Targeted knockdown of Notch3 expression by transient siRNA transfection promoted the expression of osteogenic transcription factors in normal jaw bone MSCs. Our data suggest that the loss of Notch3 signaling may contribute partly to bone outgrowth in MT, as mediated by enhanced MSC-driven osteogenic differentiation in the jaw bone.

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Section: Introductionmentioning

confidence: 99%

Loss of Notch3 Signaling Enhances Osteogenesis of Mesenchymal Stem Cells from Mandibular Torus

et al. 2016

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“…Other diagnoses that can be considered include other primary osseous tumours such as osteoma, osteochondroma, osteoblastoma, chondrosarcoma or giant cell tumour. 1,2 Non-bony differential diagnoses that may present with a firm mass or nodules include ossifying fibroma and inflammatory papillary hyperplasia. 2 While there is a history of heavy tobacco use, oral tissue malignancies such as squamous cell carcinoma (SCC) are very unlikely to present in this manner, as they occur most commonly on the tongue, floor of the mouth and vermilion border of the lower lip.…”

Section: Answermentioning

confidence: 99%

Rock ‘n’ knoll in the mouth: A man with a lump on the hard palate

Monshizadeh¹,

Emami²,

Ahmed³

et al. 2020

Aust J Gen Pract

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“…Questões relacionadas aos portadores desta condição são apresentadas na dificuldade da pronuncia de alguns fonemas, disfagia, dor na mucosa bucal (principalmente relacionados a traumas locais), dificuldade na adaptação de próteses mandibulares, cálculos, osteíte, osteomielite 1 . Algumas lesões podem se assemelhar à esta condição, destacando-se como diagnóstico diferencial: fibroma ossificante, calcinose cutânea, osteoma e osteoma osteóide [8][9][10] . Sua característica histopatológica é semelhante ao osso normal descrevendo-se osso cortical lamelar com a presença de canais de Havers, osteócitos normais e áreas dispersas de tecido conjuntivo.…”

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Aspectos clínicos e tomográficos de exostose mandibular extensa e o seu manejo para melhora na qualidade de vida: relato de um caso incomum na literatura

Mourão¹,

Mello-Machado²,

Resende³

et al. 2019

Arch Health Invest

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O tórus mandibular é considerado uma protuberância óssea (exostose) de etiologia desconhecida classificada como não-patológica, comumente vista em região lingual dos incisivos até pré-molares inferiores. Sua característica histopatológica é semelhante ao osso normal descrevendo-se osso cortical lamelar com a presença de canais de Havers, osteócitos normais e áreas dispersas de tecido conjuntivo. Normalmente se apresentam bilateralmente e indolores. Sem causar prejuízo na vida da pessoa que apresenta esta condição, devido estes aspectos, na maioria dos casos, não há intervenção cirúrgica, sendo o caso apenas acompanhado clinicamente. Neste caso apresentado, o objetivo é expor uma condição extrema desta exostose mandibular, tendo como finalidade a melhora na qualidade de vida do paciente.Descritores: Cirurgia Bucal; Exostose; Qualidade de Vida.ReferênciasKumar Singh A, Sulugodu Ramachandra S, Arora S, Dicksit DD, Kalyan CG, Singh P. Prevalence of oral tori and exostosis in Malaysian population - A cross-sectional study. J Oral Biol Craniofac Res. 2017;7(3):158-60.Hiremath VK, Husein A, Mishra N. Prevalence of torus palatinus and torus mandibularis among Malay population. J Int Soc Prev Community Dent. 2011;1(2):60-4.Sathya K, Kanneppady SK, Arishiya T. Prevalence and clinical characteristics of oral tori among outpatients in Northern Malaysia. J Oral Biol Craniofac Res. 2012;2(1):15-19.Jainkittivong A, Apinhasmit W, Swasdison S. Prevalence and clinical characteristics of oral tori in 1,520 Chulalongkorn University Dental School patients. Surg Radiol Anat. 2007;29(2):125-31.Kim YS. Pathogenetic growth potential in the central area of oral exostosis. Korean J Oral Maxillofac Pathol. 2013;37(5):201-10.Morrison MD, Tamimi F. Oral tori are associated with local mechanical and systemic factors: A case-control study. J Oral. Maxillofac Surg. 2013;71(1):14-22.García-García AS, Martínez-González JM, Gómez-Font R, Soto-Rivadeneira A, Oviedo-Roldán L. Current status of the torus palatinus and torus mandibularis. Med Oral Patol Oral Cir Bucal. 2010;15(2):e353-60.Ladizinski B, Lee KC. A nodular protuberance on the hard palate. JAMA. 2014;311(15):1558-59.Khan S, Shah SAH, Ali F, Rasheed D. Concurrence of torus palatinus, torus mandibularis and buccal exostosis. J Coll Physicians Surg Pak. 2016;26(11):111-13.Kün-Darbois JD, Guillaume B, Chappard D. Asymmetric bone remodeling in mandibular and maxillary tori. Clin Oral Investig. 2017;21(9):2781-88.Riley DS, Barber MS, Kienle GS, Aronson JK, von Schoen-Angerer T, Tugwell P et al. CARE guidelines for case reports: explanation and elaboration document. J Clin Epidemiol. 2017;89:218-35.Kucukkurt S, Özle M, Baris E. Peripheral osteoma in an unusual location on the mandible. BMJ Case Rep. 2016;2016. pii: bcr2016216554.

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A Nodular Protuberance on the Hard Palate

Cited by 6 publications

References 2 publications

Loss of Notch3 Signaling Enhances Osteogenesis of Mesenchymal Stem Cells from Mandibular Torus

Loss of Notch3 Signaling Enhances Osteogenesis of Mesenchymal Stem Cells from Mandibular Torus

Rock ‘n’ knoll in the mouth: A man with a lump on the hard palate

Aspectos clínicos e tomográficos de exostose mandibular extensa e o seu manejo para melhora na qualidade de vida: relato de um caso incomum na literatura

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