A nomogram based on serum cystatin C for predicting acute kidney injury in patients with traumatic brain injury

Abstract

Background Acute kidney injury (AKI) is a common complication in traumatic brain injury (TBI) patients and is associated with unfavorable outcome of these patients. We designed this study to explore the value of serum cystatin C, an indicator of renal function, on predicting AKI after suffering TBI. Methods Patients confirmed with TBI and hospitalized in the West China Hospital of Sichuan University between January 2015 and December 2019 were included. Patients were divided into two groups according to occurrence of AKI. Univariate and multivariate logistic regression analyses were sequentially utilized to find risk factors of AKI in included TBI patients. Nomogram composed of discovered risk factors for predicting AKI was constructed. Receiver operating characteristics (ROC) curves were drawn and area under the ROC curve (AUC) were calculated to evaluate the predictive value of cystatin C alone and the constructed nomogram. Results Among 234 included TBI patients, 55 were divided into AKI group. AKI group had shorter length of stay ( p < 0.001) and higher in-hospital mortality ( p < 0.001). Multivariate logistic regression analysis showed absolute lymphocyte count ( p = 0.034), serum creatinine ( p < 0.001), serum cystatin C ( p = 0.017) and transfusion of red blood cell ( p = 0.005) were independently associated with development of AKI after TBI. While hypertonic saline use was not associated with the development of AKI ( p = 0.067). The AUC of single cystatin C and predictive nomogram were 0.804 and 0.925, respectively. Conclusion Higher serum cystatin C is associated with development of AKI in TBI patients. Predictive nomogram incorporating cystatin C is beneficial for physicians to evaluate possibilities of AKI and consequently adjust treatment strategies to avoid occurrence of AKI.

A new model to predict acute kidney injury after cardiac surgery in patients with renal insufficiency

“…reported that serum cystatin C is a reliable biomarker in the early detection and follow-up of AKI after cardiac surgery in a cohort of children and adults, respectively [ 34 , 35 ]. Recently, another study also indicated that a predictive nomogram incorporating cystatin C was helpful to evaluate the possibilities of AKI in patients with traumatic brain injury [ 36 ].…”

Cystatin C: A Potential Predictor for Acute Kidney Injury in Patients With Community Acquired Pneumonia

“…Previously, Cystatin C had been demonstrated to be a biomarker for the early detection AKI in in other clinical settings, such as patients with traumatic brain injury, neonates, patients with cardiac surgery, patients with liver, and so on [7,[15][16][17][18]. To our best knowledge, this present study is the rst time to investigate the prognostic value of serum Cystatin C within 24 hours after admission for predicting AKI in the context of CAP with large samples, and it indeed proved to be a good predictor of AKI in patients with CAP.…”

Identification of CDK2-Related Immune Forecast Model and ceRNA in Lung Adenocarcinoma, a Pan-Cancer Analysis

“…And CDK2 was associated in the P13K-AKT ( Li Z. et al, 2021 ) signaling pathway in LUAD, inducing cell proliferation ( Wu et al, 2020 ). Combing with clinical data, we constructed the forest map and Nomogram model ( Cao et al, 2021b ; Jang et al, 2021 ; Wang R. R. et al, 2021 ; Wang K. et al, 2021 ) of clinical characteristics. Through the features of patients, we can calculate the total score to evaluate the prognosis of patients.…”