A Non-Additive Interaction of a Functional MAO-A VNTR and Testosterone Predicts Antisocial Behavior

Sjöberg, Rickard L.; Ducci, Francesca; Barr, Christina S.; Newman, Timothy K.; Dell’Osso, Liliana; Virkkunen, Matti; Goldman, David

doi:10.1038/sj.npp.1301417

Cited by 123 publications

(85 citation statements)

References 34 publications

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“…Higher levels of testosterone were associated with increased aggression scores and higher ASPD frequency only among individuals with low-activity MAOA genotype 82 .…”

Section: Alcohol Dependencementioning

confidence: 96%

O papel do polimorfismo funcional VNTR da região promotora do gene MAOA nos transtornos psiquiátricos

Nishioka¹,

Perin²,

Sampaio³

et al. 2011

Rev. psiquiatr. clín.

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Introduction: A functional variable number of tandem repeats (VNTR) polymorphism of the promoter region of the monoamine oxidase A (MAOA) gene has been described and many studies have investigated the association of this polymorphism with human behaviors, as well as with several psychiatric disorders. Objective: This study aimed to review the literature on the role of the VNTR functional polymorphism of the promoter region of the MAOA gene on the modulation of human behavior for the development of psychiatric disorders. Method: Searches on the Medline, Embase, Web of Science and PsycInfo databases were performed including works from January 1998 to June 2009. The words used were: "MAOA and human behavior" and "MAOA and psychiatry". Results: Several studies were found (N = 3,873). After the selection process, 109 papers were included in the review. There was found an association of MAOA low activity alleles with antisocial personality disorder, conduct disorder, ADHD, pathological gambling, and substance abuse. High activity alleles were associated with neuroticism, anorexia nervosa and depression and anxiety disorders. There was no association between the MAOA polymorphisms and bipolar disorder and schizophrenia. Discussion: The main findings, summarized in this paper, support a role of MAOA VNTR polymorphism in some psychiatric disorders although some divergences were found due to methodological difficulties in genetic studies. In general, the studies associated the low activity alleles with impulsivity and aggressive behavior ("hyperactive behaviors"), and the high activity alleles of the gene with "hypoactive behaviors", such as depression and anxiety, which demonstrates a modulation of the MAOA enzyme in "hyperactive" and "hypoactive" disorders.

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“…Higher levels of testosterone were associated with increased aggression scores and higher ASPD frequency only among individuals with low-activity MAOA genotype 82 .…”

Section: Alcohol Dependencementioning

confidence: 96%

O papel do polimorfismo funcional VNTR da região promotora do gene MAOA nos transtornos psiquiátricos

Nishioka¹,

Perin²,

Sampaio³

et al. 2011

Rev. psiquiatr. clín.

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“…There is a substantial body of literature connecting the variations in the COMT [Craddock et al, 2006;Thapar et al, 2005], MAOA [Kim-Cohen et al, 2006], MAOB , and DbH [Cubells and Zabetian, 2004] genes to psychopathology in general and conduct problems in particular. There is also reason to believe that risk variants in these genes can interact with each other, enhancing nonlinearly the likelihood of a negative outcome [Sjoberg et al, 2008;Talkowski et al, 2008].…”

Section: Dopaminergic Correlates Of Conduct Disordermentioning

confidence: 99%

Aggressive behavior, related conduct problems, and variation in genes affecting dopamine turnover

Grigorenko

DeYoung

Eastman

et al. 2010

Aggressive Behavior

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A number of dopamine-related genes have been implicated in the etiology of violent behavior and conduct problems. Of these genes, the ones that code for the enzymes that influence the turnover of dopamine (DA) have received the most attention. In this study, we investigated 12 genetic polymorphisms in four genes involved with DA functioning (COMT, MAOA and MAOB, and DbH) in 179 incarcerated male Russian adolescents and two groups of matched controls: boys without criminal records referred to by their teachers as (a) ''troubled-behavior-free'' boys, n 5 182; and (b) ''troubled-behavior'' boys, n 5 60. The participants were classified as (1) being incarcerated or not, (2) having the DSM-IV diagnosis of conduct disorder (CD) or not, and (3) having committed violent or nonviolent crimes (for the incarcerated individuals only). The findings indicate that, although no single genetic variant in any of the four genes differentiated individuals in the investigated groups, various linear combinations (i.e., haplotypes) and nonlinear combinations (i.e., interactions between variants within and across genes) of genetic variants resulted in informative and robust classifications for two of the three groupings. These combinations of genetic variants differentiated individuals in incarceration vs. nonincarcerated and CD vs. no-CD groups; no informative combinations were established consistently for the grouping by crime within the incarcerated individuals. This study underscores the importance of considering multiple rather than single markers within candidate genes and their additive and interactive combinations, both with themselves and with nongenetic indicators, while attempting to understand the genetic background of such complex behaviors as serious conduct problems. Aggr. Behav. 36:158-176, 2010.

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“…BGHA aggression is predicted by higher testosterone in men [64] and also has been related to functional variation of the MAOA gene. The MAOA gene was observed to interact with testosterone levels to predict aggressive behaviour measured with the BGHA [65], and FKBP5, which encodes a protein involved in cortisol response, interacts with stress exposure to predict BGHA scores [66].…”

Section: Self-reported Impulsivity In Humansmentioning

confidence: 99%

Genetics of impulsive behaviour

Bevilacqua

Goldman

2013

Phil. Trans. R. Soc. B

Self Cite

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Impulsivity, defined as the tendency to act without foresight, comprises a multitude of constructs and is associated with a variety of psychiatric disorders. Dissecting different aspects of impulsive behaviour and relating these to specific neurobiological circuits would improve our understanding of the etiology of complex behaviours for which impulsivity is key, and advance genetic studies in this behavioural domain. In this review, we will discuss the heritability of some impulsivity constructs and their possible use as endophenotypes (heritable, disease-associated intermediate phenotypes). Several functional genetic variants associated with impulsive behaviour have been identified by the candidate gene approach and re-sequencing, and whole genome strategies can be implemented for discovery of novel rare and common alleles influencing impulsivity. Via deep sequencing an uncommon HTR2B stop codon, common in one population, was discovered, with implications for understanding impulsive behaviour in both humans and rodents and for future gene discovery.

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A Non-Additive Interaction of a Functional MAO-A VNTR and Testosterone Predicts Antisocial Behavior

Cited by 123 publications

References 34 publications

O papel do polimorfismo funcional VNTR da região promotora do gene MAOA nos transtornos psiquiátricos

O papel do polimorfismo funcional VNTR da região promotora do gene MAOA nos transtornos psiquiátricos

Aggressive behavior, related conduct problems, and variation in genes affecting dopamine turnover

Genetics of impulsive behaviour

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