A non-canonical retina-ipRGCs-SCN-PVT visual pathway for mediating contagious itch behavior

Gao, Fang; Ma, Jun; Yu, Yao-Qing; Gao, Xiaofei; Bai, Yang; Sun, Yi; Liu, Juan; Liu, Xianyu; Barry, Devin M.; Wilhelm, Steven J.; Piccinni-Ash, Tyler J.; Wang, Na; Liu, Dongyang; Ross, Rachel; Yan, Hao; Huang, Xu; Jia, Jinjing; Yang, Qingchao; Zheng, Hao; Nispen, Johan van; Li, Hui; Zhang, Jiayi; Li, Yunqing; Chen, Zhou‐Feng

doi:10.1016/j.celrep.2022.111444

Cited by 10 publications

(6 citation statements)

References 119 publications

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“…In addition, in a study on the involvement of SCN GRPR neurons in contagious itch, Gao et al found SCN GRPR neurons project to PVT, and when PVT GRPR neurons were selectively inhibited, the c-fos expression of PVT GRPR neurons were reduced accompanied by contagious itch behavior decreased. 65 This indicates that SCN GRPR neurons feed excitatory information to PVT and activate PVT GRPR neurons during contagious itch behavior. This suggests that these GRPR neurons of the SCN may also be excitatory neurons.…”

Section: Conclusion and Perspectivementioning

confidence: 97%

“…And GRPR neurons transmit itch information to the paraventricular nucleus of the thalamus (PVT) via the retina-ipRGC-SCN-PVT pathway, a previously unknown visual pathway. 65 2.6. Gastric Acid Secretion (PVN, NTS, POA).…”

Section: Contagious Itch (Scn)mentioning

confidence: 99%

“…Interestingly, the additional work they did showed that visual itch information is conveyed by intrinsically photosensitive retina ganglion cells (ipRGCs) from the retina to GRP neurons via adenylate cyclase-activating polypeptide-PAC1 receptor (PACAP-PAC1R) signaling. And GRPR neurons transmit itch information to the paraventricular nucleus of the thalamus (PVT) via the retina-ipRGC-SCN-PVT pathway, a previously unknown visual pathway …”

Section: Functions Modulated By Grp/grpr Systemmentioning

confidence: 99%

“…This suggests that the presynaptic neuron releases more excitatory transmitters when the GRPR is activated; that is, the presynaptic GRPR neuron here is most likely an excitatory neuron. In addition, in a study on the involvement of SCN GRPR neurons in contagious itch, Gao et al found SCN GRPR neurons project to PVT, and when PVT GRPR neurons were selectively inhibited, the c-fos expression of PVT GRPR neurons were reduced accompanied by contagious itch behavior decreased . This indicates that SCN GRPR neurons feed excitatory information to PVT and activate PVT GRPR neurons during contagious itch behavior.…”

Section: Conclusion and Perspectivementioning

confidence: 99%

See 3 more Smart Citations

Role of the GRP/GRPR System in Regulating Brain Functions

Zhao,

Chen,

Dai

et al. 2023

ACS Chem. Neurosci.

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Section: Conclusion and Perspectivementioning

confidence: 97%

Section: Contagious Itch (Scn)mentioning

confidence: 99%

Section: Functions Modulated By Grp/grpr Systemmentioning

confidence: 99%

Section: Conclusion and Perspectivementioning

confidence: 99%

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Role of the GRP/GRPR System in Regulating Brain Functions

Zhao,

Chen,

Dai

et al. 2023

ACS Chem. Neurosci.

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“…GRPR is crucial for mediating opioid-induced itch, a clinically significant side effect of opioid analgesia ( 31 ), via cross-talk with μ-opioid receptor (MOR) isoform 1D in mice and MOR1Y in humans ( 32 , 33 ). In addition, the deletion of GRPR in the suprachiasmatic nucleus of mice abolishes contagious itch transmission ( 34 , 35 ). GRPR has been shown to be upregulated in the spinal cord of various rodent and monkey models of chronic itch and a blockade of GRPR dramatically attenuates chronic itch ( 36 – 43 ).…”

mentioning

confidence: 99%

Structures of human gastrin-releasing peptide receptors bound to antagonist and agonist for cancer and itch therapy

Peng

Zhan

Zhang

et al. 2023

Proc. Natl. Acad. Sci. U.S.A.

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Gastrin releasing peptide receptor (GRPR), a member of the bombesin (BBN) G protein-coupled receptors, is aberrantly overexpressed in several malignant tumors, including those of the breast, prostate, pancreas, lung, and central nervous system. Additionally, it also mediates non-histaminergic itch and pathological itch conditions in mice. Thus, GRPR could be an attractive target for cancer and itch therapy. Here, we report the inactive state crystal structure of human GRPR in complex with the non-peptide antagonist PD176252, as well as two active state cryo-electron microscopy (cryo-EM) structures of GRPR bound to the endogenous peptide agonist gastrin-releasing peptide and the synthetic BBN analog [D-Phe 6 , β-Ala 11 , Phe 13 , Nle 14 ] Bn (6–14), in complex with G q heterotrimers. These structures revealed the molecular mechanisms for the ligand binding, receptor activation, and G q proteins signaling of GRPR, which are expected to accelerate the structure-based design of GRPR antagonists and agonists for the treatments of cancer and pruritus.

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Circuits involving the hypothalamic suprachiasmatic nucleus for controlling diverse physiologies verified by the aid of optogenetics and chemogenetics

Hsiao,

Doi

2024

International Review of Cell and Molecular Biology

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A non-canonical retina-ipRGCs-SCN-PVT visual pathway for mediating contagious itch behavior

Cited by 10 publications

References 119 publications

Role of the GRP/GRPR System in Regulating Brain Functions

Role of the GRP/GRPR System in Regulating Brain Functions

Structures of human gastrin-releasing peptide receptors bound to antagonist and agonist for cancer and itch therapy

Circuits involving the hypothalamic suprachiasmatic nucleus for controlling diverse physiologies verified by the aid of optogenetics and chemogenetics

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