A non-coding small RNA MicC contributes to virulence in outer membrane proteins in Salmonella Enteritidis

Meng, Xianli; Cui, Weiwei; Wang, Qianqian; Wang, Jinqiu; Zhu, Guoqiang

doi:10.3791/61808

Cited by 2 publications

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Additionally, Hfq contributes to the annealing of MicC to the coding sequence of ompD mRNA and the induction of specific conformational changes [ 50 ]. Deletion of micC increased the expression of OmpD and subsequently enhanced the virulence of S. Enteritidis in mice and chickens [ 51 ]. InvR, a SPI-1-encoded sRNA, was directly activated by the major SPI-1 transcription factor HilD under invasion-inducing conditions.…”

Section: Srnas’ Functions In Salmonella –Host Inte...mentioning

confidence: 99%

Functions of Small Non-Coding RNAs in Salmonella–Host Interactions

Meng

Xia

et al. 2022

Biology

Self Cite

View full text Add to dashboard Cite

Salmonella species infect hosts by entering phagocytic and non-phagocytic cells, causing diverse disease symptoms, such as fever, gastroenteritis, and even death. Therefore, Salmonella has attracted much attention. Many factors are involved in pathogenesis, for example, the capsule, enterotoxins, Salmonella pathogenicity islands (SPIs), and corresponding regulators. These factors are all traditional proteins associated with virulence and regulation. Recently, small non-coding RNAs (sRNAs) have also been reported to function as critical regulators. Salmonella has become a model organism for studying sRNAs. sRNAs regulate gene expression by imperfect base-pairing with targets at the post-transcriptional level. sRNAs are involved in diverse biological processes, such as virulence, substance metabolism, and adaptation to stress environments. Although some studies have reported the crucial roles of sRNAs in regulating host–pathogen interactions, the function of sRNAs in host–Salmonella interactions has rarely been reviewed. Here, we review the functions of sRNAs during the infection of host cells by Salmonella, aiming to deepen our understanding of sRNA functions and the pathogenic mechanism of Salmonella.

show abstract

Section: Srnas’ Functions In Salmonella –Host Inte...mentioning

confidence: 99%