A Non‐Enzymatic and Electrochemical‐Based Sensor using a Prussian Blue‐Gold Nanoparticle‐Reduced Graphene Oxide Ternary Nanocomposite for Efficient Hydrogen Peroxide Detection.

Abstract

An electrochemical sensor has been developed using PBNCs/AuNPs/RGO ternary nanocomposite, in which gold nanoparticles (AuNPs) are deposited on Prussian blue nanocubes (PBNCs) and reduced graphene oxide (RGO) using two‐step in‐situ synthetic approach. The synthesized ternary nanocomposite shows high catalytic activity towards H2O2 sensing due to the synergistic effect of gold nanoparticles and RGO. The material was prepared by the co‐precipitation method, and the morphology of the synthesized composites was characterized using X‐Ray diffraction (XRD), scanning electron microscopy (SEM), and High‐resolution Transmission electron microscopy (HR‐TEM). Electrochemical measurements were performed by modifying glassy carbon electrodes (GCE) with bare PBNCs, PBNCs/RGO, and PBNCs/AuNPs/RGO for low‐level detection of H2O2 using Cyclic Voltammetry (CV) and Chronoamperometry. The interference property was analyzed using ascorbic acid (AA), uric acid (UA), and glucose as interfering agents. The modified electrode shows high sensitivity of 5.47 nA/nM and a limit of detection of 260 pM for H2O2 at (S/N=3). This electrochemical sensor observed a linear range of detection from 0.66 nM to 10.53 nM. The proposed sensor exhibits good stability, better selectivity, and a picomolar concentration detection limit for H2O2.

Tailored Fabrication of Defect-Rich Ion Implanted CeO2-x Nanoflakes for Electrochemical Sensing of H2O2

“…Recently, a variety of non-enzymatic sensors have been developed for sensing biomolecules, such as M-BDC metal-organic frameworks 20 and NiO-MoO 3 nanocomposite for sensing glucose, 21 as well as CuO/black phosphorous nanohybrids 22 and PBNCs/AuNPs/RGO nanocomposite for sensing H 2 O 2 . 23 A variety of nanostructured oxides, such as ZnO, Fe 2 O 3 , TiO 2 and CeO 2 have demonstrated desirable functional, biocompatible, and non-toxic properties, enabling their use in non-enzymatic electrochemical biosensors. 24 Among oxides, CeO 2 is a promising candidate for non-enzymatic biosensors owing to its excellent electronic conductivity and oxygen diffusivity which arises from its ability to create oxygen vacancies upon switching from Ce 4+ to Ce 3+ .…”