A Non-invasive Modality: The US Virtual Touch Tissue Quantification (VTTQ) for Evaluation of Breast Cancer

Tamaki, Kentaro; Tamaki, Nobuharu; Kamada, Yoshihiko; Uehara, Kanou; Miyashita, Minoru; Ishida, Toru; Sasano, Hironobu

doi:10.1093/jjco/hyt098

Cited by 19 publications

(15 citation statements)

References 30 publications

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“…Being the quantitative measurement of shear wave elastography based on acoustic radiation force impulse (ARFI), Virtual Touch Tissue Quantification (VTTQ) (Nightingale et al 2002;Fahey et al 2007;McAleavey et al 2007;Tamaki et al 2013) is a quantitative measurement of shear wave velocity generated by ARFI, allowing both the qualitative visual and quantitative evaluation of the elasticity of the tissue concerned. This method could evaluate the stiffness of tissues such as muscles, tendons, abdominal organ, breast and prostate, providing complementary mechanical characteristics of the tissue concerned, in addition to conventional physical and morphological information provided by sonogram.…”

Section: Introductionmentioning

confidence: 99%

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Non-Invasive Evaluation of Axillary Lymph Node Status in Breast Cancer Patients Using Shear Wave Elastography

Tamaki¹,

Tamaki²,

Kamada³

et al. 2013

Tohoku J. Exp. Med.

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Less invasive procedures are currently required to examine the axillary lymph node status. Shear wave elastography with acoustic radiation force impulse provides objective and reproducible quantification of the intrinsic property of the soft tissue. In this study, we measured shear wave velocity of the axillary lymph nodes of patients with breast cancer using Virtual Touch Tissue Quantification (VTTQ). The degree of lymph node metastasis was evaluated by measuring the expression level of cytokeratin 19 (CK19) mRNA, a specific marker for breast cancer cells. The one-step nucleic acid amplification (OSNA) was used to determine the copy number of CK19 mRNA in 149 lymph node specimens of 149 primary breast cancer patients. Axillary lymph node status according to OSNA (copy number/μl) were categorized as 0-249 copies (−), 250-5,000 copies (+), and copy number > 5,000 (++). A category (−) represents no metastasis in the axillary lymph node. There were 121 patients with OSNA−, 9 with OSNA+ and 19 with OSNA++. The average velocities according to OSNA categories were 1.64 ± 0.42 m/second for OSNA−, 2.25 ± 0.78 m/second for OSNA+, and 2.79 ± 0.98 m/second for OSNA++. There were significant differences in the shear wave velocity between OSNA− and OSNA+ (P = 0.040) or OSNA++ (P < 0.001). The most optimal cutoff velocity to distinguish benign from metastasis is 1.44 m/second, as determined using the receiver operating characteristic method. The shear wave velocity measured with VTTQ could provide clinically useful information about axillary lymph node metastasis in patients with primary breast cancer.

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Section: Introductionmentioning

confidence: 99%

“…This potentially improves the characterization of tissues and focal lesions in an objective way. VTTQ thus represents a good tool for the quantification of the intrinsic property of the tissue, and could provide objective and reproducible data (Nightingale et al 2002;Fahey et al 2007;McAleavey et al 2007;Tamaki et al 2013).…”

Section: Introductionmentioning

confidence: 99%

Non-Invasive Evaluation of Axillary Lymph Node Status in Breast Cancer Patients Using Shear Wave Elastography

Tamaki¹,

Tamaki²,

Kamada³

et al. 2013

Tohoku J. Exp. Med.

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“…To overcome this limitation, shear wave imaging including point shear wave speed (SWS) measurement and SWS imaging has been introduced into clinical practice. Point SWS measurement such as virtual touch tissue quantification (VTQ; Siemens Medical Solutions, Mountain View, CA, USA) can measure the SWS of tissue and several studies showed that point SWS measurement is useful in differentiation between benign and malignant breast lesions101112. Nonetheless, point SWS measurement is not able to provide two-dimensional (2D) stiffness distribution of target lesion.…”

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confidence: 99%

Qualitative and quantitative analysis with a novel shear wave speed imaging for differential diagnosis of breast lesions

Yang

Guo

et al. 2017

Sci Rep

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To evaluate the diagnostic performance of a new two-dimensional shear wave speed (SWS) imaging (i.e. Toshiba shear wave elastography, T-SWE) in differential diagnosis of breast lesions. 225 pathologically confirmed breast lesions in 218 patients were subject to conventional ultrasound and T-SWE examinations. The mean, standard deviation and ratio of SWS values (m/s) and elastic modulus (KPa) on T-SWE were computed. Besides, the 2D elastic images were classified into four color patterns. The area under the receiver operating characteristic (AUROC) curve analysis was performed to evaluate the diagnostic performance of T-SWE in differentiation of breast lesions. Compared with other quantitative T-SWE parameters, mean value expressed in KPa had the highest AUROC value (AUROC = 0.943), with corresponding cut-off value of 36.1 KPa, sensitivity of 85.1%, specificity of 96.6%, accuracy of 94.2%, PPV of 87.0%, and NPV of 96.1%. The AUROC of qualitative color patterns in this study obtained the best performance (AUROC = 0.957), while the differences were not significant except for that of Eratio expressed in m/s (AUROC = 0.863) (P = 0.03). In summary, qualitative color patterns of T-SWE obtained the best performance in all parameters, while mean stiffness (36.05 KPa) provided the best diagnostic performance in the quantitative parameters.

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“…Virtual Touch tissue quantification enables a simultaneous quantitative evaluation of tissue stiffness by measuring the SWV. Acoustic radiation force impulse imaging does not require any external stress, even in deep tissues, and is less operator dependent compared with strain elastography . Nevertheless, LNs with superficial locations and soft compositions may decrease the effectiveness of SWVs …”

Section: Discussionmentioning

confidence: 99%

Diagnostic Performance of Acoustic Radiation Force Impulse Elastography for the Differentiation of Benign and Malignant Superficial Lymph Nodes: A Meta‐analysis

Chen

Cao

et al. 2019

J of Ultrasound Medicine

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To estimate the diagnostic performance of acoustic radiation force impulse elastography in distinguishing between benign and malignant superficial lymph nodes, relevant articles published before October 31, 2018, in China and other countries were used. Conclusively, a total of 18 articles were analyzed. Sixteen studies used Virtual Touch tissue quantification (Siemens Healthineers, Erlangen, Germany), and 4 studies used Virtual Touch tissue imaging (Siemens Healthineers). After a meta‐analysis, it was found that acoustic radiation force impulse elastography is an efficient method for detecting superficial lymph nodes. In addition, if the cutoff value for the shear wave velocity were less than 2.85 m/s, the summary sensitivity would increase, and the heterogeneity would be reduced.

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A Non-invasive Modality: The US Virtual Touch Tissue Quantification (VTTQ) for Evaluation of Breast Cancer

Cited by 19 publications

References 30 publications

Non-Invasive Evaluation of Axillary Lymph Node Status in Breast Cancer Patients Using Shear Wave Elastography

Non-Invasive Evaluation of Axillary Lymph Node Status in Breast Cancer Patients Using Shear Wave Elastography

Qualitative and quantitative analysis with a novel shear wave speed imaging for differential diagnosis of breast lesions

Diagnostic Performance of Acoustic Radiation Force Impulse Elastography for the Differentiation of Benign and Malignant Superficial Lymph Nodes: A Meta‐analysis

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