A Nondestructive Surface Zwitterionization of Polydimethylsiloxane for the Improved Human Blood-inert Properties

Dizon, Gian Vincent; Clarin, Maria Thea Rane; Venault, Antoine; Tayo, Lemmuel L.; Chiang, Heng-Chieh; Zheng, Jie; Aimar, Pierre; Chang, Yung

doi:10.1021/acsabm.8b00212

Cited by 13 publications

(10 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…PDMS has been widely used in the biomedical area for fabrication of devices such as catheters, pacemakers, and drainage implants. 49 However, the strong hydrophobic nature and high surface friction of PDMS implants may cause pain and unfeeling when coming in contact with tissues. This ultralow-friction PDA− PSBMA coating will dramatically improve the water affinity and reduce interface friction of PDMS devices.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

Mussel-Inspired One-Step Fabrication of Ultralow-Friction Coatings on Diverse Biomaterial Surfaces

et al. 2019

View full text Add to dashboard Cite

Low-friction and hydrophilic surfaces have critical applications in biomedical devices and implants. Existing methods to achieve such surfaces, for example, grafting polymer brushes, usually suffer from tedious steps and harsh reaction conditions, which limit practical applications. In this work, we propose a set of versatile ultralow-friction coatings applicable for diverse biomaterial surfaces via a one-step simple codeposition strategy with dopamine and hydrophilic monomers. The polymer coatings show ultralow-friction performance together with hydrophilic feature and antifouling property. The coefficient of friction of the as-prepared coating can be as low as 0.003 in pure water. The coating also provides superior and stable lubrication in biological fluids due to antifouling capability. Furthermore, the versatility of this strategy allows fabrication of multiple lubricious polymer coatings with different hydrophilic monomers and on diverse material surfaces. The typical application of this low-friction coating on a medical catheter was further demonstrated, which dramatically improved surface wettability and reduced friction of the outer surface of the catheter. In view of the versatility and remarkable lubrication ability, the multifunctional coatings may find important applications in biomedical devices and implants.

show abstract

Section: ■ Results and Discussionmentioning

confidence: 99%

Mussel-Inspired One-Step Fabrication of Ultralow-Friction Coatings on Diverse Biomaterial Surfaces

et al. 2019

View full text Add to dashboard Cite

show abstract

“…Besides, zwitterionic compound like SBMA has good antifouling property and biocompatibility. When applied as a wound dressing, PSBMA would efficiently inhibit bacterial adhesion and lower the degree of activation of platelets. , The zwitterionic polyelectrolyte hydrogels with inherent adhesion and intrinsic antibacterial ability have great potentials for wound dressings and electronic skin.…”

Section: Resultsmentioning

confidence: 99%

Antibacterial Zwitterionic Polyelectrolyte Hydrogel Adhesives with Adhesion Strength Mediated by Electrostatic Mismatch

Wang

et al. 2020

ACS Appl. Mater. Interfaces

100

View full text Add to dashboard Cite

Biotissue adhesives and antibacterial materials have great potential applications in wound dressing, implantable devices, and bioelectronics. In this study, stretchable tissue adhesive hydrogels with intrinsic antibacterial properties have been demonstrated by copolymerizing zwitterionic monomers with ionic monomers. The hydrogels are stretchable to about 900% strain and show a modulus of 4−9 kPa. The zwitterionic moieties provide strong dipole−dipole interaction, electrostatic interaction, and hydrogen bonding with the skin surface, and thus show adhesion strength values of 1−4 kPa to skin. Meanwhile, the copolymerized cationic or anionic monomers break the intrinsic electrostatic stoichiometry of the zwitterionic units and thus mediate the electrostatic interactions and the adhesion strength with the surface. The stretchable hydrogels form a robust and compliant (due to low modulus and stretchability) adhesive to skin, rubber, glass, and plastics, and could be repeatedly peeled-off and readhered to the skin. Moreover, the abundant quaternary ammonium (QA) groups in the zwitterionic moieties and the added QA groups endow it outstanding antibacterial properties (>99%). These stretchable tissue adhesive antibacterial hydrogels are promising for wound dressings and implantable devices.

show abstract

“…Zwitterions have several applications in live cell imaging [54,55], antibacterial surfaces [56] and wound dressings [57], dental applications [58], separative membrane coatings [59], and most importantly blood purification [51]. Academic efforts over immobilization of ZWs on hemodialysis membranes have been reported over different membrane materials (cellulose acetate (CA) [60], poly(ether sulfone) (PES) [61][62][63], poly(sulfone) (PSF) [64], poly(dimethyl siloxane) (PDMS) [65], poly(vinylidene fluoride) (PVDF) [66], etc.) using various chemical immobilization approaches.…”

Section: Hemocompatibility Enhancementsmentioning

confidence: 99%

Challenges and Advances in Hemodialysis Membranes

Mollahosseini¹,

Abdelrasoul²,

Shoker³

2020

Advances in Membrane Technologies

View full text Add to dashboard Cite

Hemodialysis (HD) is a filtration vital process through which the bloods' toxins and contaminations are removed. However, several immune system activations occur during dialysis, which can result in morbidity and mortality. The efficiency of the currently available blood purification process is hindered, on one hand, by the deficient toxins and middle molecule removal, and on the other hand, with the loss of valuable blood components (such as plasma and its constituents). This chapter offers an overview of the challenges and advances in HD membranes. It includes an introduction of the end stage renal disease, concepts of dialysis, its historical background, and the path through which the configurations and materials evolved. The interactions between membrane polymeric materials with human blood is also discussed. The aspect of material modification is one of the critical areas in HD technology as it targets to solve the most immediate and prevalent HD issue of membrane bioincompatibility. High flux dialysis (HFD) and hemofiltration (HF) are introduced and discussed. This class of membranes was introduced to solve middle molecule (such as β2-microglobulin) related challenges. This chapter highlights the question of why the issue of incompatible materials still exists along with current membrane modifications.

show abstract

A Nondestructive Surface Zwitterionization of Polydimethylsiloxane for the Improved Human Blood-inert Properties

Cited by 13 publications

References 48 publications

Mussel-Inspired One-Step Fabrication of Ultralow-Friction Coatings on Diverse Biomaterial Surfaces

Mussel-Inspired One-Step Fabrication of Ultralow-Friction Coatings on Diverse Biomaterial Surfaces

Antibacterial Zwitterionic Polyelectrolyte Hydrogel Adhesives with Adhesion Strength Mediated by Electrostatic Mismatch

Challenges and Advances in Hemodialysis Membranes

Contact Info

Product

Resources

About