The received signal strength difference (RSSD) localization is a kind of method to locate emission sources by measuring the differences of received signal strength level between the monitoring stations and is essentially the truth value ratios of measured signal strength. In the existing literatures, only the rule of RSSD localization circle of two monitoring stations and the geometric relation of RSSD localization circle of five monitoring stations were analyzed, but the number and the station layout of the minimum RSSD localization network have not been investigated. In the present work, first, based on the existing RSSD localization equation, the constants of the commonly used wave propagation models are provided. Then, the minimum RSSD localization network is proved through algebraic analysis, which is that four monitoring stations not distributed on a straight line can locate the signal source at one point. The relationship between the localization accuracy and the signal strength error of the RSSD location network with different scales is studied further and formulated as a nonlinear programming optimization problem. It is found that the localization stability of the network with four stations is poor, and there is a serious localization deviation outlier phenomenon. Therefore, the network with four stations is not available for radio monitoring networks with a signal strength error of ± 5 to ± 10 dB. The RSSD network with five stations is basically the minimum available size, and the RSSD network with nine stations can approach the localization accuracy of the angle of arrival (AOA) network with three stations.