A Nonrandomized Trial of Progressive Resistance Training Intervention in Women With Polycystic Ovary Syndrome and Its Implications in Telomere Content

Furtado, Cristiana Libardi Miranda; Ramos, Frederico Faleiro; Kogure, Gislaine Satyko; Santana-Lemos, Bárbara A.; Ferriani, Rui Alberto; Calado, Rodrigo T.; Reis, Rosana Maria dos

doi:10.1177/1933719115611753

Cited by 40 publications

(67 citation statements)

References 64 publications

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“…In one of the few longitudinal studies, a four-month RT intervention in women with polycystic ovary syndrome, a shortening of telomeres was demonstrated [13]. In our study, 56% and 44% of participants experienced telomere shortening and lengthening, respectively.…”

Section: Discussionmentioning

confidence: 60%

“…Conversely, others examined telomere length changes following a six-month resistance training intervention in elderly subjects residing in a nursing home and observed no differences between experimental or control groups [12]. Further, a 16-week study examining the effect of three times weekly RT in a group of women with polycystic ovarian syndrome found telomere shortening in both the experimental and control group [13]. Therefore, whether RT maintains or accelerates biological ageing through telomere length regulation remains unclear.…”

Section: Introductionmentioning

confidence: 99%

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The Effect of Resistance Training on Telomere Length in Women Recovering from Breast Cancer

Hagstrom¹,

Denham²

2018

JFMK

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Abstract:The purpose of this exploratory analysis was to examine the effects of resistance training (RT) on leukocyte telomere length in breast cancer survivors. Samples from 33 breast cancer survivors were analysed following a 16-week RT or usual care intervention (RT: n = 19, control: n = 14). The RT group performed supervised exercise three times per week. Leukocyte telomere length was assessed before and after training using quantitative PCR. Changes in telomere length were analysed using ANCOVA, with the change score being the dependent variable, and the baseline value the covariate. Effect sizes (ES) were calculated via partial eta squared. We found a non-statistically significant change in telomere length, and a small associated ES in the RT group compared to the control group for change in telomere length (p = 0.78, ES = 0.003). Our exploratory study demonstrates that a 16-week RT intervention does not have a significant effect on telomere length in women recovering from breast cancer. Therefore, RT is a safe intervention that does not accelerate biological ageing.

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Section: Discussionmentioning

confidence: 60%

Section: Introductionmentioning

confidence: 99%

The Effect of Resistance Training on Telomere Length in Women Recovering from Breast Cancer

Hagstrom¹,

Denham²

2018

JFMK

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“…Twenty weeks of aerobic compared with combined exercise, along with a high‐protein diet, showed similarly improved PCOS features 52,54–56 . Small RCTs and high‐quality mechanistic studies (cohort and case control studies) show physical activity, including formal exercise (aerobic and muscle strengthening) that improves body composition and clinical features, 52,54–66 compared with minimal or no interventions. These benefits occur independent of significant weight loss and can occur with exercise alone 57,67 …”

Section: Resultsmentioning

confidence: 95%

Evidence summaries and recommendations from the international evidence‐based guideline for the assessment and management of polycystic ovary syndrome: Lifestyle management

et al. 2020

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Summary Lifestyle is fundamental in chronic disease prevention and management, and it has been recommended as a first‐line treatment in the Australian polycystic ovary syndrome (PCOS) guideline 2011. The first international evidence‐based guideline on PCOS was developed in 2018, which expanded the scope and evidence in the Australian guideline. This paper summarizes the lifestyle recommendations and evidence summaries from the guideline. International multidisciplinary guideline development groups delivered the International Evidence‐based Guideline for the Assessment and Management of Polycystic Ovary Syndrome 2018. The process followed the Appraisal of Guidelines for Research and Evaluation II and The Grading of Recommendations, Assessment, Development and Evaluation framework. Extensive communication and meetings addressed six prioritized clinical questions through five reviews. Evidence‐based recommendations were formulated before consensus voting within the panel. Evidence shows the benefits of multicomponent lifestyle intervention, efficacy of exercise and weight gain prevention with no specific diet recommended. Lifestyle management is the first‐line management in the intervention hierarchy in PCOS. Multicomponent lifestyle intervention including diet, exercise and behavioural strategies is central to PCOS management with a focus on weight and healthy lifestyle behaviours. The translation programme optimizes reach and dissemination for health professionals and consumers.

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“… 40 The main patient characteristics in all studies included age, BMI and weight. Some studies included body FM, abdominal FM or body fat percentage, 42 45 and others included waist circumference or waist to hip ratio. 39 41 …”

Section: Discussionmentioning

confidence: 99%

Can resistance training improve the symptoms of polycystic ovary syndrome?

Pericleous

Stephanides

2018

BMJ Open Sport Exerc Med

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ObjectivesIt has been suggested that the symptoms of Polycystic Ovary Syndrome (PCOS) could be improved by resistance training.DesignThis review focuses on identifying studies that use resistance training to examine how it can affect the symptoms of polycystic ovary syndrome (PCOS).MethodsMedline, Cochrane, Dare and PubMed databases were searched to find relevant articles. All studies were assessed in terms of their design and methods.ResultsWe found 10 studies that used resistance training to examine how it affects the symptoms of PCOS.ConclusionsThere is a need for further investigation. Most studies that examine the effects of resistance training on the symptoms of PCOS needed to consider the diet (macronutrient) of the participants along with the resistance training to have a better picture of how resistance training can affect the PCOS symptoms. Many questions are still unanswered.

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A Nonrandomized Trial of Progressive Resistance Training Intervention in Women With Polycystic Ovary Syndrome and Its Implications in Telomere Content

Abstract: Progressive resistance training had positive effects on the hormonal and physical characteristics of women with PCOS and controls, but telomere content was reduced and homocysteine level increased in all participants.

Cited by 40 publications

References 64 publications

The Effect of Resistance Training on Telomere Length in Women Recovering from Breast Cancer

The Effect of Resistance Training on Telomere Length in Women Recovering from Breast Cancer

Evidence summaries and recommendations from the international evidence‐based guideline for the assessment and management of polycystic ovary syndrome: Lifestyle management

Can resistance training improve the symptoms of polycystic ovary syndrome?

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