A Nonsynonymous Substitution of Lhx3 Leads to Changes in Body Size in Dogs and Mice
Wanyi Dang,
Dali Gao,
Guangqi Lyu
et al.
Abstract:Lhx3 is a LIM-homeodomain transcription factor that affects body size in mammals by regulating the secretion of pituitary hormones. Akita, Shiba Inu, and Mame Shiba Inu dogs are Japanese native dog breeds that have different body sizes. To determine whether Lhx3 plays a role in the differing body sizes of these three dog breeds, we sequenced the Lhx3 gene in the three breeds, which led to the identification of an SNP in codon 280 (S280N) associated with body size. The allele frequency at this SNP differed sign… Show more
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