2007
DOI: 10.1007/s10815-007-9163-4
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A normal birth following preimplantation genetic diagnosis by FISH determination in the carriers of der(15)t(Y;15)(Yq12;15p11) translocations: two case reports

Abstract: Purpose To investigate the clinical application of fluorescence in situ hybridization (FISH) for assessing chromosome disorders of embryos in preimplantation diagnosis of carriers with der(15)t(Y;15)(q12;p11) translocations.

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Cited by 10 publications
(7 citation statements)
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“…Finally, the short arm of an acrocentric chromosome can be enlarged due to an unbalanced translocation of Yq12 material (cases 6-8). Most frequently observed are der(15)t(Y;15)(q12;p13) (Chen et al 2007), while corresponding derivatives of chromosomes 13 (Morris et al 1987), 14 (Buys et al 1979), 21 (Ng et al 2006), or 22 are rarely or have not been seen up to now.…”
Section: Discussionmentioning
confidence: 99%
“…Finally, the short arm of an acrocentric chromosome can be enlarged due to an unbalanced translocation of Yq12 material (cases 6-8). Most frequently observed are der(15)t(Y;15)(q12;p13) (Chen et al 2007), while corresponding derivatives of chromosomes 13 (Morris et al 1987), 14 (Buys et al 1979), 21 (Ng et al 2006), or 22 are rarely or have not been seen up to now.…”
Section: Discussionmentioning
confidence: 99%
“…Our results demonstrate that standard karyotyping, in combination with FISH, is useful for the detection of rare chromosomal rearrangements. Some cases with Prader-Willi syndrome (PWS) exhibit translocations involving chromosome 15 with deletion of PWS regions [2,[7][8][9][10]. However, by using CEP 15 (Fig.…”
Section: Discussionmentioning
confidence: 99%
“…The most frequent translocation of this type occurs between the heterochromatin of the long arm of chromosome Y and the short arm of chromosome 15 [1,2]. This may be the result of a frequent sequence homology based association of the 15p and Yq heterochromatin, during the pachytene stage of male meiosis [3].…”
Section: Introductionmentioning
confidence: 99%
“…As loss or gain of Yq12 band does not cause any phenotypic abnormality [Kühl et al, 2001; Chen et al, 2007], the phenotype and prognosis of these fetuses were expected to be the same as for 12qter deletion and duplication cases.…”
Section: Discussionmentioning
confidence: 99%