:This talk introduces the most widely used modern life science research, and its new developments in the 21 st century, discovers the formation, breakthroughs, and developments of computing life science, discusses the carrier of computing life sciences, the ramification of biological mathematics, mathematical theory and its disciplinary characteristics, explores the research methodologies of computing life science. The study shows that while in the 21 st century, the crossovers and intersections of mathematics, computational science, and the life science speed up. Computing life science methods are trying to interpret life sciences from a new perspective. It adopts a new research model and this will turn applied mathematics from non-life to life, thus greatly strengthens the interpenetration and connection of mathematics, computational science, and life sciences, which decisively advances the research of life science.