We investigate the topological degree for generalized monotone operators of class (S)+ with compact set-valued perturbations. It is assumed that perturbations can be represented as the composition of a continuous single-valued mapping and an upper semicontinuous set-valued mapping with aspheric values. This allows us to extend the standard degree theory for convex-valued operators to set-valued mappings whose values can have complex geometry. Several theoretical aspects concerning the definition and main properties of the topological degree for such set-valued mappings are discussed. In particular, it is shown that the introduced degree has the homotopy invariance property and can be used as a convenient tool in checking the existence of solutions to corresponding operator inclusions. To illustrate the applicability of our approach to studying models of real processes, we consider an optimal feedback control problem for the steady-state internal flow of a generalized Newtonian fluid in a 3D (or 2D) bounded domain with a Lipschitz boundary. By using the proposed topological degree method, we prove the solvability of this problem in the weak formulation.