This paper is concerned with the synchronization of memristor-based chaotic system subject to actuator saturation via variable impulsive control. Firstly, a memristor-based circuit model is considered, and an impulsive controller subject to actuator saturation is designed. Based on the Lyapunov stability theory and some inequality techniques, some sufficient conditions are derived to guarantee the asymptotic synchronization of the memristor-based chaotic systems. Compared with the common fixed impulsive control, the variable impulsive control used in this paper is more reliable in practical application. Finally, the numerical simulations are given to verify the effectiveness of the proposed method.