A note on some Enterobacteriaceae from the faeces of small wild British mammals

Healing, T. D.; Kaplan, C.; Prior, Anne

doi:10.1017/s0022172400063415

Cited by 6 publications

(3 citation statements)

References 3 publications

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“…All tested samples were free from Salmonella and this result is congruent with previous studies from the United Kingdom and Canada that regardless of the isolation method reported none or low level (1%) of Salmonella carriage in various rodent species including mice and voles derived from natural, landfill, and farm environments [ 16 , 17 , 18 , 19 ]. Those findings are contradictory to the research on commensal rodents that thrive in the vicinity of human settlements and can serve as vectors in pathogen transmission.…”

Section: Discussionsupporting

confidence: 90%

Salmonella and Antimicrobial Resistance in Wild Rodents—True or False Threat?

et al. 2020

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Transmission of pathogenic and resistant bacteria from wildlife to the bacterial gene pool in nature affects the ecosystem. Hence, we studied intestine content of five wild rodent species: the yellow-necked wood mouse (Apodemus flavicollis, n = 121), striped field mouse (Apodemus agrarius, n = 75), common vole (Microtus arvalis, n = 37), bank vole (Myodes glareolus, n = 3), and house mouse (Mus musculus, n = 1) to assess their potential role as an antimicrobial resistance (AMR) and Salmonella vector. The methods adopted from official AMR monitoring of slaughtered animals were applied and supplemented with colistin resistance screening. Whole-genome sequencing of obtained bacteria elucidated their epidemiological relationships and zoonotic potential. The study revealed no indications of public health relevance of wild rodents from the sampled area in Salmonella spread and their limited role in AMR dissemination. Of 263 recovered E. coli, the vast majority was pan-susceptible, and as few as 5 E. coli showed any resistance. In four colistin-resistant strains neither the known mcr genes nor known mutations in pmr genes were found. One of these strains was tetracycline-resistant due to tet(B). High diversity of virulence factors (n = 43) noted in tested strains including ibeA, cdtB, air, eilA, astA, vat, pic reported in clinically relevant types of enteric E. coli indicate that rodents may be involved in the ecological cycle of these bacteria. Most of the strains represented unique sequence types and ST10805, ST10806, ST10810, ST10824 were revealed for the first time, showing genomic heterogeneity of the strains. The study broadened the knowledge on phylogenetic diversity and structure of the E. coli population in wild rodents.

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Section: Discussionsupporting

confidence: 90%

Salmonella and Antimicrobial Resistance in Wild Rodents—True or False Threat?

et al. 2020

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“…Despite various attempts, no Salmonella isolate was detected in any of the fecal samples tested. These results support the finding of other researchers that Salmonella occurs very infrequently in wild small animals (13,15,28). The low rate of occurrence of E. coli and the absence of Salmonella in the gastrointestinal tracts of wild small mammals may be attributable to the diet of these animals, which can vary depending on the geographic location, the population density, and seasonal variations in the food supply (21,38).…”

Section: Ery Of Nonfastidious Organisms Such As Enterobacteriaceaesupporting

confidence: 90%

Antimicrobial Resistance in Escherichia coli Isolates from Swine and Wild Small Mammals in the Proximity of Swine Farms and in Natural Environments in Ontario, Canada

Kozak

Janecko

Reid‐Smith

et al. 2009

Appl Environ Microbiol

272

159

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Wild animals not normally exposed to antimicrobial agents can acquire antimicrobial agent-resistant bacteria through contact with humans and domestic animals and through the environment. In this study we assessed the frequency of antimicrobial resistance in generic Escherichia coli isolates from wild small mammals (mice, voles, and shrews) and the effect of their habitat (farm or natural area) on antimicrobial resistance. Additionally, we compared the types and frequency of antimicrobial resistance in E. coli isolates from swine on the same farms from which wild small mammals were collected. Animals residing in the vicinity of farms were five times more likely to carry E. coli isolates with tetracycline resistance determinants than animals living in natural areas; resistance to tetracycline was also the most frequently observed resistance in isolates recovered from swine (83%). Our results suggest that E. coli isolates from wild small mammals living on farms have higher rates of resistance and are more frequently multiresistant than E. coli isolates from environments, such as natural areas, that are less impacted by human and agricultural activities. No Salmonella isolates were recovered from any of the wild small mammal feces. This study suggests that close proximity to food animal agriculture increases the likelihood that E. coli isolates from wild animals are resistant to some antimicrobials, possibly due to exposure to resistant E. coli isolates from livestock, to the resistance genes of these isolates, or to antimicrobials through contact with animal feed.

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“…Rodents do not seem to represent reservoir hosts for pathogenic strains of E. coli (e.g. Healing et al, 1980 ; Kilonzo et al, 2013 ), which was in agreement with our findings (see also Swiecicka et al, 2003 ; Kozak et al, 2009 ). The presence of the bacterium may be related to gut microbiota variations due to diet seasonality ( Ecke et al, 2018 ; Gebczynska, 1983 ; Hansson, 1979 , 1985 ).…”

Section: Discussionsupporting

confidence: 93%