Non-trivial K-theory groups and non-trivial cobordism groups can lead to global symmetries which are conjectured to be absent in quantum gravity. Inspired by open-closed string duality, we propose a correspondence between the two groups, which can be considered as the physical manifestation of a generalisation of the classic Conner-Floyd isomorphism. The picture is exemplified by the relations between KO-groups and Spincobordisms and between K-groups and Spin c -cobordisms. We mainly focus on the case in which the global symmetries are eventually gauged and, by combining K-theory and cobordism, we recover tadpole cancellation conditions in type I string theory and F-theory from a purely bottom-up perspective. In the spirit of the swampland program, we provide a prescription to compute the relative normalisation between cobordism and K-theory charges in these tadpoles, without relying on string theory input.