The problem of finding perfect Euler cuboids or proving their nonexistence is an old unsolved problem in mathematics. The third cuboid conjecture is the last of the three propositions suggested as intermediate stages in proving the non-existence of perfect Euler cuboids. It is associated with a certain Diophantine equation of the order 12. In this paper a structural theorem for the solutions of this Diophantine equation is proved.Conjecture 1.1 (third cuboid conjecture). For any three positive coprime integer numbers a, b, and u such that none of the conditions (1.2) is satisfied the polynomialThe subcases 2, 5, and 6 in (1.2) are trivial. The subcase 1 leads to the first cuboid conjecture. The subcases 3 and 4 lead to the second cuboid conjecture. The first, the second, and the third cuboid conjectures were introduced [1]. They