Let S be a set of primes. We call an m-tuple (a 1 , . . . , am) of distinct, positive integers S-Diophantine, if for all i = j the integers s i,j := a i a j + 1 have only prime divisors coming from the set S, i.e. if all s i,j are S-units. In this paper, we show that no S-Diophantine quadruple (i.e. m = 4) exists if S = {3, q}. Furthermore we show that for all pairs of primes (p, q) with p < q and p ≡ 3 mod 4 no {p, q}-Diophantine quadruples exist, provided that (p, q) is not a Wieferich prime pair.2010 Mathematics Subject Classification. 11D61, 11D45.