A Note on the Survival and Growth of Human and Rabbit Tissues (Normal and Neoplastic) on the Chorio‐allantois of the Chick and Duck Embryo

Hurst, E. Weston; Cooke, Barbara Ternent; McLennan, GC

doi:10.1038/icb.1939.21

Cited by 18 publications

(3 citation statements)

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“…al . 52 first demonstrated that a human tumor of the central nervous system (meningioma) could be successfully transplanted to the CAM. Since then, Vogel, et.…”

Section: Application Of the Cam In Glioma Researchmentioning

confidence: 99%

Application of the Chick Embryo Chorioallantoic Membrane in Neurosurgery Disease

Yuan¹,

Xu²,

Wu³

et al. 2014

Int. J. Med. Sci.

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The chick embryo chorioallantoic membrane (CAM) is a highly vascularized extraembryonic membrane. Because of its ease of accessibility, extensive vascularization and immunodeficient environment, the CAM has been broadly used in the oncology, biology, pharmacy, and tissue regeneration research. The present review summarizes the application of the CAM in neurosurgery disease research. We focused on the use of the CAM as an assay for the research of glioma, vascular anomalies, Moyamoya Disease, and the blood-brain barrier.

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“…al . 52 first demonstrated that a human tumor of the central nervous system (meningioma) could be successfully transplanted to the CAM. Since then, Vogel, et.…”

Section: Application Of the Cam In Glioma Researchmentioning

confidence: 99%

Application of the Chick Embryo Chorioallantoic Membrane in Neurosurgery Disease

Yuan¹,

Xu²,

Wu³

et al. 2014

Int. J. Med. Sci.

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“…The recognition that the chicken egg CAM could be used as a human PDX scaffold came from early studies performed by Holland Stevenson in 1918 and Hurst in 1939, where several patient carcinomas that were predominantly from breast were engrafted on the CAM [ 144 , 145 ]. Results from the Stevenson studies indicated that CAM-engrafted human tumors do not propagate well with the basic nutrients provided by the CAM, although they did resemble the parent tumor [ 145 ].…”

Section: In Vivo Modeling Platformsmentioning

confidence: 99%

“…Results from the Stevenson studies indicated that CAM-engrafted human tumors do not propagate well with the basic nutrients provided by the CAM, although they did resemble the parent tumor [ 145 ]. Hurst et al would repeat the experiments on the CAM using carcinomas from various different patients including breast tumors and were able to generate viable tumor xenografts on the chick embryo scaffold [ 144 ]. The success of engraftment continued to improve modestly with Sommers in 1952 and Kaufman in 1956, who both attempted to engraft breast carcinomas amongst other tumor [ 146 , 147 ].…”

Section: In Vivo Modeling Platformsmentioning

confidence: 99%

In Vivo Modeling of Human Breast Cancer Using Cell Line and Patient-Derived Xenografts

Souto

Dobrolecki

Villanueva

et al. 2022

J Mammary Gland Biol Neoplasia

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Historically, human breast cancer has been modeled largely in vitro using long-established cell lines primarily in two-dimensional culture, but also in three-dimensional cultures of varying cellular and molecular complexities. A subset of cell line models has also been used in vivo as cell line-derived xenografts (CDX). While outstanding for conducting detailed molecular analysis of regulatory mechanisms that may function in vivo, results of drug response studies using long-established cell lines have largely failed to translate clinically. In an attempt to address this shortcoming, many laboratories have succeeded in developing clinically annotated patient-derived xenograft (PDX) models of human cancers, including breast, in a variety of host systems. While immunocompromised mice are the predominant host, the immunocompromised rat and pig, zebrafish, as well as the chicken egg chorioallantoic membrane (CAM) have also emerged as potential host platforms to help address perceived shortcomings of immunocompromised mice. With any modeling platform, the two main issues to be resolved are criteria for “credentialing” the models as valid models to represent human cancer, and utility with respect to the ability to generate clinically relevant translational research data. Such data are beginning to emerge, particularly with the activities of PDX consortia such as the NCI PDXNet Program, EuroPDX, and the International Breast Cancer Consortium, as well as a host of pharmaceutical companies and contract research organizations (CRO). This review focuses primarily on these important aspects of PDX-related research, with a focus on breast cancer.

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Chorioallantoic membrane heterotransplantation of human brain tumors

Vogel

Berry

1975

Intl Journal of Cancer

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Specimens of human tumors were taken from the operating room and directly heterotransplanted to chick chorioallantoic membranes. Seventy-one percent of the eggs survived the procedure and 41% of the tumors appeared viable after 1 week. Microscopically, the first-generation heterotransplants resembled the parent tumors. Many specimens showed evidence of growth, but in most of them there was also some degree of necrosis. The necrosis increased with serial heterotransplantation, so that tumor propagation usually was not possible beyond the second to third transplant generation; nevertheless, it was found that almost any histological type of intracranial tumor could be grown for short periods of time at least on the chick chorioallantoic membrane.

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A Note on the Survival and Growth of Human and Rabbit Tissues (Normal and Neoplastic) on the Chorio‐allantois of the Chick and Duck Embryo

Cited by 18 publications

References 0 publications

Application of the Chick Embryo Chorioallantoic Membrane in Neurosurgery Disease

Application of the Chick Embryo Chorioallantoic Membrane in Neurosurgery Disease

In Vivo Modeling of Human Breast Cancer Using Cell Line and Patient-Derived Xenografts

Chorioallantoic membrane heterotransplantation of human brain tumors

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