In this study, we extend the generalized multilinear variable separation approach to a fifth-order nonlinear evolution equation. By performing asymptotic analysis on the variable separation solution, which is composed of three lower-dimensional functions, we identify a resonant regime governing dromion-dromion/solitoff interactions. In the case of two-dromion interactions, elastic, inelastic, and completely inelastic collisions are possible, while for the dromion-solitoff interaction only inelastic and completely inelastic collisions are permitted. Furthermore, we derive two types of semi-rational solutions from the quadratic function ansatz. In particular, in the scenario of a completely resonant collision between a lump and a line-soliton pair, the lump separates from one line soliton and exists briefly before merging with the other soliton, forming a localized lump in both time and space dimensions. The fusion or fission phenomena between the dromion-dromion/solitoff interaction and the lump-line soliton interaction are shown graphically.