A Novel 3,9-(1,2,3-Trioxocine)-Type Steroid of Rauia nodosa (Rutaceae)

Abstract

Abstract:A new natural product, a 3,9-(1,2,3-trioxocine)-type steroid, named rauianodoxy (6), was isolated from Rauia nodosa, together with five steroids: sistostenone (1), stigmastenone (2), sitosterol (3), stigmasterol (4) and ergosterol peroxide (5), one coumarin, O-geranylosthenol (7), and three alkaloids, N-methylflindersine (8), zantobungeanine (9) and veprissine (10). Compounds 5-8 were isolated for the first time in the genus Rauia. These compounds were characterized on the basis of their spectral data, mainly one and twodimensional NMR, and mass spectra, also involving comparison with the literature data. Theoretical studies at the DFT level reveal structural parameters for the 1,2,3-trioxole bridge compatible with known structures containing a similar group.

Spectrophotometric and chromatographic strategies for exploring of the nanostructure pharmaceutical formulations which contains testosterone undecanoate

“…Absorption maxima of TU are influenced by with solvent polarity. Solvation of TU molecules occurs via dipole-dipole interactions in non-H-bond donating solvents, inasmuch as in H-bond donating solvents the occurrence is more H-bonding 25,26 .…”

Biocidal effect of Ergosterol-Propyl Ester Isolated From Ruta angustifolia (Pers.) on Spodopetra littoralis (Boisd.)

“…Furthermore, many scientists had been isolated ergosterol derivatives which naturally produced in some plants and fungi. Rocha et al, (2014) isolated five steroids from the stems of Rauia nodosa (Rutaceae) sistostenone, stigmastenone, sitosterol, stigmaasterol and ergosterol peroxide, one coumarin, O-geranylosthenol and three alkaloids, N-methylflindersine , zantobungeanine and veprissine.…”

Antiprotozoal and Antitumor Activity of Natural Polycyclic Endoperoxides: Origin, Structures and Biological Activity

“…A unique compound, a 3,9-(1,2,3-trioxocine)-type steroid called rauianodoxy ( 133 ), and an ergosterol peroxide ( 33 ) were isolated from the Australian plant Rauia nodosa (family Rutaceae) [ 217 ]. An unusual endoperoxide called schinalactone A ( 134 ), which has a compressed ring A and shows anticancer activity against PANC-1 cell lines, was detected in the stems and roots of the magnolia vine, Schisandra sphenanthera [ 218 ].…”