2023
DOI: 10.2174/1871520622666220905122346
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A Novel 6,8,9-Trisubstituted Purine Analogue Drives Breast Cancer Luminal A Subtype MCF-7 to Apoptosis and Senescence through Hsp70 Inhibition

Abstract: Background: Cancer cells restrain apoptotic and senescence pathways through Heat Shock Protein 70 (Hsp 70) at the intracellular level. These cells aid stimulus-independent growth and their higher metabolism rate requires Hsps. Hsps compensate abnormally increased substrate protein folding rate of cancer cells. Objective: Misfolding of substrate proteins specially signaling substrate proteins may not function properly therefore, Hsp70 folds these substrate proteins into their native-fully functional states, a… Show more

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