A novel acridone derivative for the fluorescence tagging and mass spectrometric sequencing of peptides

Acridone‐Benzimidazole Ring‐Fused Ligands: A New Class of Sensitizers of Lanthanide Luminescence via Low‐Energy Excitation

“…Acridone, used as a tag in fluorescence-based assays, [30,31] has been grafted as a pendant arm on macrocyclic cyclen-based ligands by Faulkner's group [27] in order to sensitize Eu III luminescence. Advantages of such a heterocycle include its chemical inertness, its remarkable resistance to photobleaching and, above all, the possibility to be excited around 400-420 nm.…”

Ethyl (9-oxo-9,10-dihydroacridin-10-yl)acetate

“…For general background, see: Agiamarnioti et al (2006); Boużyk et al (2003); Faller et al (1997); Reymond et al (1996). For related structures, see: Dobrzynska & Turowska-Tyrk (1997); Dzyabchenko et al (1980); Zavodnik et al (1979Zavodnik et al ( , 1981.…”

“…Comment 9-Acridinones strongly fluoresce in visible region (Boużyk et al, 2003) which brings about that they can serve as emitting fragments of fluorogenic indicators or labels. 9-Acridinone derivatives attached through a spacer to macromolcules have been applied among others in fluorometric assay of peptides (Faller et al, 1997) and avidin or streptavidin (Agiamarnioti et al, 2006). A highly sensitive assay for antibody catalysis has also been demonstrated by using a number of 9-acridinone labelled compounds (Reymond et al, 1996).…”

Tandem Access to Acridones and their Fused Derivatives: [1+2+3] Annulation of Isocyanides with Unsaturated Carbonyls

“…[2a,5] Moreover, the acridones are also served as useful building blocks for the construction of organic semiconductors, [6] dyestuffs and fluorescent labels. [7] As a consequence, great effort has been devoted to developing new protocols for their preparation. Up to now, the synthetic methods mainly rely on (i) the intramolecular cyclization of the corresponding Narylsubstituted acids, amides, and ketones (Scheme 1, path a) [8] as well as 2-aminobenzophenones (Scheme 1, path b and c), [9] (ii) the palladium/copper co-catalyzed oxidative carbonylation of diphenylamines with CO (Scheme 1, path d); [10] and Cu(II)-mediated cascade reaction of o-amino acetophenones and phenylboronic acids (Scheme 1, path e); [11] (iii) the annulation of anthranilic acid derivatives with aryne or aryliodonium (Scheme 1, path f [12] and g [13] ).…”