A novel AIE “on-off-on” fluorescence sensor for highly selective and sensitive sequential detection of Fe3+ and HSO3− in foods

Bisulfite (HSO 3À ) is associated with many physiological processes in living systems. High concentration of HSO 3 À may lead to many diseases. Herein, a simple levulinate-based colorimetric fluorescent probe for HSO 3 À detection was designed and synthesized. The probe showed high selectivity for HSO 3 À detection with color changes from light pink to deep pink.Under the optimal test conditions, there is a good linear relationship between fluorescence intensity and concentrations of HSO 3 À in the range of 0-50 μM with detection limit of 1.04 nM. In addition, the probe was successfully applied to monitor HSO 3 À in living cells and zebrafish, which proved that the probe can be used to detect HSO 3 À in living systems.

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“…À ) is a class of reactive sulfur species and plays very important roles in biological systems, [1][2][3] food and drinks industry. [4] HSO 3…”

Section: Bisulfite (Hsomentioning

confidence: 99%

A Novel Levulinate‐Based Highly Specific Colorimetric Fluorescent Probe for Bisulfite Detection in Live Cells and Zebrafish

et al. 2022

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“…Iron deficiency anemia is widespread in all countries of the world, and iron deficiency will affect the normal operation of our human system and lead to various diseases. Iron deficiency appears to affect dopamine and norepinephrine synthesis and catabolism, which causes sleep, learning and memory disorders [3]. In order to maintain the stability of iron content in the body, diet should be adjusted in time according to the situation.…”

Section: Introductionmentioning

confidence: 99%

“…In this work, Fe 3+ was detected based on its quenching effect on the fluorescence of NZC-CDs in aqueous media and on paper test strips. Paper test strip is promising alternative method for practical use based on its simplicity, rapidity and low reagent consumption [3,29]. Fluorometric testing can be usually performed by dipping paper test strips coated with fluorescence reagents into a sample, for which color changes appear on the paper under UV lamp [30,31].…”

Section: Introductionmentioning

confidence: 99%

Paper test strip for fluorescence detection of iron ion based on nitrogen, zinc and copper codoped carbon dots

Yang,

Jiang,

Zhang

et al. 2023

Methods Appl. Fluoresc.

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In this study, a test strip for fluorometric analysis of iron ion (Fe3+) was constructed based on nitrogen, zinc and copper codoped carbon dots (NZC-CDs) as fluorescence probes. NZC-CDs were synthesized by hydrothermal method. The optical properties, appearance, size, components and crystal state of NZC-CDs were characterized by ultraviolet (UV), fluorescence, infrared, TEM, XPS and XRD techniques. NZC-CDs exhibited bright blue fluorescence under UV lamp with a quantum yield at 17.4%. The fluorescence of NZC-CDs was quenched by Fe3+ in the presence of Fe3+ possibly due to the aggregation induced quenching. The possible fluorescence quenching mechanism was also discussed. The quenching fluorescence was linear with the concentration of Fe3+in the range of 2.5-400 μM with a low detection limit of 0.50 μM. For the convenient detection, the test strips based on filter paper were employed for Fe3+ assay. Moreover, the present approach was successfully applied in the determination of Fe3+ in real samples including black fungus, duck blood and pork liver. The sensing method had the potential application in more food analysis.

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“…Cancer cells have hyperoxidative stress caused by a lack of reactive oxygen species (ROS) consumption system and broken ROS homeostasis. , High levels of ROS have a negative impact on tumor cells, and thus, the amplification of oxidative stress can kill cancer cells . Ferroptosis can cause a Fenton or Fenton-like reaction, thus leading to the amplification of intracellular ROS levels. − Excessive production of ROS may disrupt normal cellular homeostasis, lead to nonspecific damage of key components, and lead to a range of diseases. Using this mechanism to generate oxidative stress in tumor cells, thereby stimulating tumor cells to inhibit their growth, is a very valuable strategy. , However, cells tend to keep redox balance, and thus, the concentration of reduced glutathione (GSH) is usually 7–10 times higher than that in normal cells .…”

Section: Introductionmentioning

confidence: 99%

Increasing the Production of Reactive Oxygen Species through a Ferroptosis Pathway Disrupts the Redox Balance of Tumor Cells for Cancer Treatment

Yang

Song

et al. 2022

ACS Appl. Polym. Mater.

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Disruption of the balance of cellular redox can increase the cellular concentration of reactive oxygen species (ROS), which leads to oxidative stress-induced apoptosis in cancer cells, therefore minimizing the toxic effects on normal cells. However, this strategy is incomplete in programmable anticancer drug delivery. On the basis of this strategy, we designed, synthesized, and successfully functionalized an amphiphilic copolymer [poly(ethylene glycol) monomethyl ether (mPEG)-b-poly(hydroxyethyl methylacrylate)(PHEMA))-g-SS-hydroxybenzenoborate pinanol ester(HPBAe)/hydroxyethylferrocene (Fc)] that can form stable micelles in water and effectively load the hydrophobic drug doxorubicin (DOX). 1H NMR was used to confirm the structure of the polymers. Transmission electron microscopy (TEM) revealed that the blank or drug-loaded micelles were spherical. Blank micelles displayed negligible cytotoxicity. Ferrocene reacted with H2O2 to form hydroxyl radicals (·OH) through a Fenton or Fenton-like reaction for an enhanced antioxidant ability of cancer cells. H2O2-induced self-destruction of PHEMA can then release quinone methide (QM), which depletes glutathione (GSH) and suppresses the antioxidant capacity of tumor cells. This process can effectively attack cancerous cells through the synergistic effects of DOX, thus maximizing the therapeutic impact. Confocal microscopy also displayed that the drug could be efficiently delivered and released by micelles. Finally, the nano drug loading system containing ferrocene and pinacol phenylborate can actively increase the level of ROS in 4T1 cells and effectively kill 4T1 cells. This amphiphilic copolymer micelle is a stimuli-responsive nanomaterial and a promising therapeutic approach for cancer.

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A novel AIE “on-off-on” fluorescence sensor for highly selective and sensitive sequential detection of Fe3+ and HSO3− in foods

Cited by 19 publications

References 38 publications

A Novel Levulinate‐Based Highly Specific Colorimetric Fluorescent Probe for Bisulfite Detection in Live Cells and Zebrafish

A Novel Levulinate‐Based Highly Specific Colorimetric Fluorescent Probe for Bisulfite Detection in Live Cells and Zebrafish

Paper test strip for fluorescence detection of iron ion based on nitrogen, zinc and copper codoped carbon dots

Increasing the Production of Reactive Oxygen Species through a Ferroptosis Pathway Disrupts the Redox Balance of Tumor Cells for Cancer Treatment

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