A novel alginate-gelatin microcapsule to enhance bone differentiation of mesenchymal stem cells

Samadian, S.; Karbalaei, Atiyeh; Pourmadadi, Mehrab; Yazdian, Fatemeh; Rashedi, Hamid; Omidi, Meisam; Malmir, Samira

doi:10.1080/00914037.2020.1848828

Cited by 41 publications

(21 citation statements)

References 58 publications

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“…In the in vivo test, the composite also enhanced the zebrafish jawbone regeneration and increased the mineral density of the injured site. At the molecular level, it is now confirmed that this phenomenon is achieved through the activation of the BMP/Smad signaling pathway, which mediates the expression of osteogenic-related genes and proteins. , A recently published study further proved that CDs can enhance the ALP activity of stem cells derived from human fat (hBFPSCs) . When used as a part of the composite materials, the addition of CDs was proven to increase mechanical strength, cell adhesion, and proliferation as well. ,− Meanwhile, since CDs also have a fluorescent tracing effect, they can be used to observe the process of intracellular osteogenic differentiation .…”

Section: Carbon-based Nanomaterials For Bone and Cartilage Regenerationmentioning

confidence: 99%

“…At the molecular level, it is now confirmed that this phenomenon is achieved through the activation of the BMP/Smad signaling pathway, which mediates the expression of osteogenic-related genes and proteins. , A recently published study further proved that CDs can enhance the ALP activity of stem cells derived from human fat (hBFPSCs) . When used as a part of the composite materials, the addition of CDs was proven to increase mechanical strength, cell adhesion, and proliferation as well. ,− Meanwhile, since CDs also have a fluorescent tracing effect, they can be used to observe the process of intracellular osteogenic differentiation . Besides, experiments using mice and MSCs as models confirmed the osteogenic effects of CDs themselves. ,,, To be specific, Geng et al observed a prominent increase of the ALP activity and the mineralized matrix of hMSCs after being treated with negatively charged GQD .…”

Section: Carbon-based Nanomaterials For Bone and Cartilage Regenerationmentioning

confidence: 99%

“…123,127 A recently published study further proved that CDs can enhance the ALP activity of stem cells derived from human fat (hBFPSCs). 122 When used as a part of the composite materials, the addition of CDs was proven to increase mechanical strength, cell adhesion, and proliferation as well. 122,201−203 Meanwhile, since CDs also have a fluorescent tracing effect, they can be used to observe the process of intracellular osteogenic differentiation.…”

Section: Carbon-based Nanomaterials For Bone and Cartilage Regenerationmentioning

confidence: 99%

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Carbon-Based Nanomaterials for Bone and Cartilage Regeneration: A Review

Liu

Chen

Qiao

et al. 2021

ACS Biomater. Sci. Eng.

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As the main load-bearing structure in the human body, bone and cartilage are susceptible to damage in sports and other activities. The repair and regeneration of bone and articular cartilage have been extensively studied in the past decades. Traditional approaches have been widely applied in clinical practice, but the effect varies from person to person and may cause side effects. With the rapid development of tissue engineering and regenerative medicine, various biomaterials show great potential in the regeneration of bone and cartilage. Carbonbased nanomaterials are solid materials with different structures and properties composed of allotropes of carbon, which are classified into zero-, one-, and two-dimensional ones. This Review systemically summarizes the different types of carbon-based nanomaterials, including zero-dimensional (fullerene, carbon dots, nanodiamonds), one-dimensional (carbon nanotubes), and two-dimensional (graphenic materials) as well as their applications in bone, cartilage, and osteochondral regeneration. Current limitations and future perspectives of carbon-based nanomaterials are also discussed.

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Section: Carbon-based Nanomaterials For Bone and Cartilage Regenerationmentioning

confidence: 99%

Section: Carbon-based Nanomaterials For Bone and Cartilage Regenerationmentioning

confidence: 99%

Section: Carbon-based Nanomaterials For Bone and Cartilage Regenerationmentioning

confidence: 99%

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Carbon-Based Nanomaterials for Bone and Cartilage Regeneration: A Review

Liu

Chen

Qiao

et al. 2021

ACS Biomater. Sci. Eng.

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“…As above-mentioned, these cells have the ability to differentiate into different cells such as adipocytes, chondrocytes, osteoblasts, myoblasts, and neuron-like cells. This ability has resulted in successful application of MSCs in tissue and scaffold engineering [ 89 – 91 ].…”

Section: Therapeutic Mechanisms Of Mscsmentioning

confidence: 99%

The Clinical Trials of Mesenchymal Stromal Cells Therapy

Kouchakian

Baghban

Moniri

et al. 2021

Stem Cells International

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Mesenchymal stromal cells (MSCs) are a heterogeneous population of adult stem cells, which are multipotent and possess the ability to differentiate/transdifferentiate into mesodermal and nonmesodermal cell lineages. MSCs display broad immunomodulatory properties since they are capable of secreting growth factors and chemotactic cytokines. Safety, accessibility, and isolation from patients without ethical concern make MSCs valuable sources for cell therapy approaches in autoimmune, inflammatory, and degenerative diseases. Many studies have been conducted on the application of MSCs as a new therapy, but it seems that a low percentage of them is related to clinical trials, especially completed clinical trials. Considering the importance of clinical trials to develop this type of therapy as a new treatment, the current paper is aimed at describing characteristics of MSCs and reviewing relevant clinical studies registered on the NIH database during 2016-2020 to discuss recent advances on MSC-based therapeutic approaches being used in different diseases.

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“…8 Biopolymers are composed of non-toxic natural compounds and are therefore inherently biocompatible, 9,10 and this biocompatibility of biopolymers has been extended to medical applications. 11 Some biopolymers gradually break down in the body; this feature makes them suitable for tissue replacement or drug delivery in the body. 12 Bacterial cellulose, which is synthesized by non-pathogenic bacteria such as Acetobacter xyleneium, as a natural polymer with unique properties including good mechanical and physical properties, 13 biocompatibility, 14 high porosity, high water absorption capacity, oxygen permeability, and absorption of wound secretions, 15 which is ideal for use in wound dressing and medical applications.…”

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confidence: 99%

PVA based nanofiber containing cellulose modified with graphitic carbon nitride/nettles/trachyspermum accelerates wound healing

Nemati

Ashjari

Rashedi

et al. 2021

Biotechnology Progress

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Today, bacterial cellulose has received a great deal of attention for its medical applications due to its unique structural properties such as high porosity, good fluid uptake, good strength, and biocompatibility. This study aimed to fabricate and study bacterial cellulose/graphitic carbon nitride/nettles/trachyspermum nanocomposite by immersion and PVA/BC/g-C 3 N 4 /nettles/trachyspermum nanofiber by electrospinning method as a wound dressing. The g-C 3 N 4 and g-C 3 N 4 solution were synthesized and then were characterized using Fourier transform infrared, X-ray diffraction, Zeta Potential, and scanning electronic microscope analyzes. Also, the antibacterial properties of the synthesized materials were proved by gram-positive and gram-negative bacteria using the minimum inhibitory concentration method.Besides, the toxicity, migration, and cell proliferation results of the synthesized materials on NIH 3T3 fibroblasts were evaluated using MTT and scratch assays and showed that the BC/PVA/g-C 3 N 4 /nettles/trachyspermum composite not only had no toxic effect on cells but also contributed to cell survival, cell migration, and proliferation has done. To evaluate the mechanical properties, a tensile strength test was performed on PVA/BC/g-C 3 N 4 /nettles/trachyspermum nanofibers, and the results showed good strength of the nanocomposite. In addition, in vivo assay, the produced nanofibers were used to evaluate wound healing, and the results showed that these nanofibers were able to accelerate the wound healing process so that after 14 days, the wound healing percentage showed 95%. Therefore, this study shows that PVA/BC/g-C 3 N 4 /nettles/trachyspermum nanofibers effectively inhibit bacterial growth and accelerate wound healing.

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A novel alginate-gelatin microcapsule to enhance bone differentiation of mesenchymal stem cells

Cited by 41 publications

References 58 publications

Carbon-Based Nanomaterials for Bone and Cartilage Regeneration: A Review

Carbon-Based Nanomaterials for Bone and Cartilage Regeneration: A Review

The Clinical Trials of Mesenchymal Stromal Cells Therapy

PVA based nanofiber containing cellulose modified with graphitic carbon nitride/nettles/trachyspermum accelerates wound healing

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