A novel amphiphilic pH-responsive AIEgen for highly sensitive detection of protamine and heparin

Wang, Xuefeng; Jiang, Qin; Man, Yuecuo; Feng, Shengyu; Lee, Yong‐Ill; Liu, Hong-Guo

doi:10.1016/j.snb.2018.01.130

Cited by 32 publications

(10 citation statements)

References 59 publications

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“…Similar work was reported by Hu, Li et al 101 and Zhu, Zhang et al 102 with ammonium modified TPE derivative 28 or silole derivative 29. Besides the typical AIE-gens such as TPE and silole, fluorescent probes 30 and 31 with other AIE-gens were reported by Tong's 103 and Liu's 104 groups, which were all demonstrated suitable for heparin monitoring during postoperative and long-term care (0.2−1.2 U/mL). 89 In order to increase the signal-to-noise ratio, ACQ probe 32 was introduced to the heparin−protamine interaction system.…”

Section: Heparinmentioning

confidence: 96%

Sugar-Based Aggregation-Induced Emission Luminogens: Design, Structures, and Applications

et al. 2020

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Sugars are abundant natural sources existing in biological systems, and bioactive saccharides have attracted much more attention in the field of biochemistry and biomaterials. For better understanding of the sugar-based biomaterials and biological sciences, aggregation-induced emission luminogens (AIE-gens) have been widely employed for detection, tracing, and imaging. This review covers the applications of AIE molecules on sugar-based biomaterials by three parts, polysaccharide, oligosaccharide, and monosaccharide, mainly focusing on saccharide detection, stimuli response materials preparation, bioimaging, and study of the AIE mechanism. These excellent works suggest the promising future of the sugar-based AIE bioconjugates, considering that the naturally designed and elaborately functionalized saccharides play discriminate roles in biological processes and AIE-tagged species may work as an indicator in each case. However, there are a lot of sugar-based biological species that have not been touched, such as mucopolysaccharides and glycoproteins on the cell surface and in the cell plasma. Based on these features, we enthusiastically look forward to more glorious developments in this bright research area.

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Section: Heparinmentioning

confidence: 96%

Sugar-Based Aggregation-Induced Emission Luminogens: Design, Structures, and Applications

et al. 2020

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Section: Detection Of Miscellaneous Proteins Via Aie‐promoted Protein Imagingmentioning

confidence: 99%

“…Wang et al . [ 58 ] have designed an amphiphilic pH‐responsive tetraphenylbenzene derivative (6‐(1,3‐dioxo‐4,5,6,7‐tetraphenylisoindolin‐2‐yl) hexanoic acid) named TPHA for detecting protamine and heparin, as shown in Figures 4(A)–4(C). The fluorescence power of TPHA in a mixture of acidic THF/water improved dramatically when the water content increased due to the formation of the aggregates, while it coped with feeble fluorescence in basic THF/water mixtures.…”

Section: Detection Of Miscellaneous Proteins Via Aie‐promoted Protein...mentioning

confidence: 99%

AIEgen‐enhanced protein imaging: Probe design and sensing mechanisms

et al. 2021

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Proteins are the building blocks of life, regarded as one of the most complex and crucial biomacromolecules in biological systems, and playing a significant role in executing genes and transferring genetic information. According to recent research, due to the structural intricacy of proteins and their sensitivity to physical and chemical degradation processes, they could be utilized as biomarkers or therapeutic agents in the diagnosis, treatment, or even prevention of different diseases. Therefore, modern pathways have been developed for understanding the function of proteins, resulting in intriguing approaches in the field of protein‐related diseases. The diagnostic strategies to deal with such diseases, including protein analysis, protein quantification, and protein imaging, were argued in depth. Meanwhile, the aggregation‐induced emission (AIE) concept and its potential applications for real‐time imaging make AIE luminogens (AIEgen) attractive for protein imaging. In general, AIEgens refer to those luminogenic chemicals that are nonluminescent in solution, but luminescent in either the aggregated or solid states. This review is focused on the emergence of AIE materials in protein tracking, detecting, and imaging for medical applications.

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“…The intramolecular motion of AIEgens can be restricted not only by the surrounding environment but also by the formation of complexes/aggregates with other molecules. To recognize protamine, Wang et al synthesized an AIE biosensor with a carboxyl group ( 31 , Figure ). In a Tris‐HCl buffer at pH 9.0, 31 was dissolved due to the deprotonation of carboxyl moieties.…”

Section: Strategies To Realize Accurate Detection Using Aie Probesmentioning

confidence: 99%

A new approach to developing diagnostics and therapeutics: Aggregation‐induced emission‐based fluorescence turn‐on

Guo

Song

et al. 2019

Medicinal Research Reviews

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Fluorescence imaging is a promising visualization tool and possesses the advantages of in situ response and facile operation; thus, it is widely exploited for bioassays. However, traditional fluorophores suffer from concentration limits because they are always quenched when they aggregate, which impedes applications, especially for trace analysis and real‐time monitoring. Recently, novel molecules with aggregation‐induced emission (AIE) characteristics were developed to solve the problems encountered when using traditional organic dyes, because these new molecules exhibit weak or even no fluorescence when they are in free movement states but emit intensely upon the restriction of intramolecular motions. Inspired by the excellent performances of AIE molecules, a substantial number of AIE‐based probes have been designed, synthesized, and applied to various fields to fulfill diverse detection tasks. According to numerous experiments, AIE probes are more practical than traditional fluorescent probes, especially when used in bioassays. To bridge bioimaging and materials engineering, this review provides a comprehensive understanding of the development of AIE bioprobes. It begins with a summary of mechanisms of the AIE phenomenon. Then, the strategies to realize accurate detection using AIE probes are discussed. In addition, typical examples of AIE‐active materials applied in diagnosis, treatment, and nanocarrier tracking are presented. In addition, some challenges are put forward to inspire more ideas in the promising field of AIE‐active materials.

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A novel amphiphilic pH-responsive AIEgen for highly sensitive detection of protamine and heparin

Cited by 32 publications

References 59 publications

Sugar-Based Aggregation-Induced Emission Luminogens: Design, Structures, and Applications

Sugar-Based Aggregation-Induced Emission Luminogens: Design, Structures, and Applications

AIEgen‐enhanced protein imaging: Probe design and sensing mechanisms

A new approach to developing diagnostics and therapeutics: Aggregation‐induced emission‐based fluorescence turn‐on

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