A novel and effective therapy for Zoon balanitis: Topical crisaborole 2% ointment

Niu, Xuping; Yang, Xuyan; Wang, Fang; Hou, Ruixia; Yao, Lei; Han, Qixin; Liu, Yeqiang

doi:10.1111/jdv.18494

Cited by 3 publications

(2 citation statements)

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“…Patients suffering from ZB in our study underwent surgical circumcision. As data from several years of follow-up showed, there was no recurrence of the disease, which confirms the effectiveness of the selected treatment method, which is consistent with the results of other clinical trials [6][7][8][9]. On the other hand, circumcision is an invasive method, and pharmacological treatment methods can replace surgical techniques.…”

Section: Discussionsupporting

confidence: 85%

“…Histologically, ZB is characterized by diamond-or lozenge-shaped flattened keratinocytes, while number and location of plasma cells may vary [5]. Topical treatment is based mostly on the use of corticosteroids, calcineurin inhibitors, antibiotics (such as mupirocin or fusidic acid), and recently 2 topical tacrolimus [5,20], however the most effective treatment is circumcision, probably because of removing the cause of the irritation [6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

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Zoon’s Balanitis as a Separate Type of Balanitis with the Characteristic Pattern of Pro-Inflammatory Cytokines Expression

Czajkowski,

Czajkowska,

Wierzbicki

et al. 2023

Preprint

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Zoon balanitis (ZB) is a mild and chronic inflammatory dermatosis that mostly affects uncircumcised men of middle and old age. The etiology of this disease remains unknown. Moreover, some authors have questioned the presence of this type of balanitis. Our study aimed to assess the expression of proinflammatory cytokines in ZB and demonstrate the presence of a characteristic expression pattern, different from that reported in the literature for penile lichen sclerosus(LS) and penile cancer. Skin biopsies from four foreskins affected by Zoon’s balanitis with surrounding morphologically unchanged skin and 13 from nonlesional foreskins (healthy control adult males undergoing circumcision) were obtained. RNA was extracted from each biopsy, followed by quantitative assessment of the gene expression of interleukin 1-A(IL-1A), interleukin 1-B(IL-1B),interleukin 1 receptor antagonist(IL-1RN),interleukin 6(IL-6), transforming growth factor β1(TGF-β1), and interferon-gamma(INF-γ). The decreased level of IL-1A mRNA was observed in Zoon’s balanitis in both inflamed and healthy skin compared to control samples. There were no statistically significant differences in other investigated cytokines gene expression between Zoon’s balanitis and the control group. In conclusion, the expression of proinflammatory cytokines was not related to the course of zoon balanitis. Moreover, in the case of IL-1A, we observed the suppression of the immune response.

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Section: Discussionsupporting

confidence: 85%