A novel and highly divergent Arabidopsis cyclin isolated by complementation in budding yeast

Abrahams, Sharon; Cavet, Guy; Oakenfull, E. Ann; Carmichael, Jeremy P.; Shah, Zahid H.; Soni, Rajeev; Murray, James A. H.

doi:10.1016/s0167-4889(01)00106-9

Cited by 16 publications

(8 citation statements)

References 22 publications

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“…Several groups reported that aggregation prone proteins can sequester other non-aggregating proteins, provided that they are structurally similar to each other (Garcia-Mata et al, 2002;Suhr et al, 2001). Since D2SV harbors the majority of wellconserved cyclin box sequence (Abrahams et al, 2001), we reasoned that the intracellular aggregates formed by this protein might sequester other cell cycle proteins containing a cyclin box or cyclin box interacting domains by a process previously described as analogue co-aggregation (Garcia-Mata et al, 2002). In cells overexpressing D2SV, we found that this protein coaggregates with endogenous or transfected cell cycle proteins such as cycD1, cycD2, cycB1 and CDK4.…”

Section: D2sv and Cell Cycle Regulationmentioning

confidence: 99%

A splice variant of cyclin D2 regulates cardiomyocyte cell cycle through a novel protein aggregation pathway

Sun

Zhang

Wafa

et al. 2009

Journal of Cell Science

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Section: D2sv and Cell Cycle Regulationmentioning

confidence: 99%

A splice variant of cyclin D2 regulates cardiomyocyte cell cycle through a novel protein aggregation pathway

Sun

Zhang

Wafa

et al. 2009

Journal of Cell Science

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“…Also, the human K/L/T-and Arabidopsis T-types of cyclins are distantly related to the C-and H-type cyclins, whereas the U-type cyclins might be even more distantly related. In addition to these and the D-type cyclins, there are two more cyclins, SDS and CycJ18 (Abrahams et al, 2001;Azumi et al, 2002), which are quite isolated from others and thus need to be treated as two separate classes. In this paper, we call them SDSand CycJ18-type cyclins, respectively (Fig.…”

Section: The Arabidopsis Cyclins Can Be Grouped Into 10 Typesmentioning

confidence: 99%

Genome-Wide Analysis of the Cyclin Family in Arabidopsis and Comparative Phylogenetic Analysis of Plant Cyclin-Like Proteins

et al. 2004

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Cyclins are primary regulators of the activity of cyclin-dependent kinases, which are known to play critical roles in controlling eukaryotic cell cycle progression. While there has been extensive research on cell cycle mechanisms and cyclin function in animals and yeasts, only a small number of plant cyclins have been characterized functionally. In this paper, we describe an exhaustive search for cyclin genes in the Arabidopsis genome and among available sequences from other vascular plants.Based on phylogenetic analysis, we define 10 classes of plant cyclins, four of which are plant-specific, and a fifth is shared between plants and protists but not animals. Microarray and reverse transcriptase-polymerase chain reaction analyses further provide expression profiles of cyclin genes in different tissues of wild-type Arabidopsis plants. Comparative phylogenetic studies of 174 plant cyclins were also performed. The phylogenetic results imply that the cyclin gene family in plants has experienced more gene duplication events than in animals. Expression patterns and phylogenetic analyses of Arabidopsis cyclin genes suggest potential gene redundancy among members belonging to the same group. We discuss possible divergence and conservation of some plant cyclins. Our study provides an opportunity to rapidly assess the position of plant cyclin genes in terms of evolution and classification, serving as a guide for further functional study of plant cyclins.Progression of the eukarytotic cell cycle is primarily controlled by a family of Ser/Thr protein kinases known as cyclin-dependent kinases (CDKs). The catalytic activity of CDKs is dependent on cyclin binding and activation, and can be further regulated by several additional mechanisms. These include protein phosphorylation/dephosphorylation, direct binding of CDK inhibitor protein (CKI) and CDK subunit (CKS), proteolysis, and intracellular trafficking (

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“…Poorly characterized groups of cyclins include L, T, C, and H families from plants and animals, and some divergent groups of plant cyclins designated SOLO DANCERS (Azumi et al, 2002), J (Abrahams et al, 2001), and either U (Wang et al, 2004) or P (Torres Acosta et al, 2004). Some of the U/P family members can bind CDKA in a yeast two-hybrid assay (Torres Acosta et al, 2004), but there is no direct evidence for their cell cycle involvement.…”

Section: Cyclin Familymentioning

confidence: 99%

Genome-Wide Annotation and Expression Profiling of Cell Cycle Regulatory Genes in Chlamydomonas reinhardtii

2005

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Eukaryotic cell cycles are driven by a set of regulators that have undergone lineage-specific gene loss, duplication, or divergence in different taxa. It is not known to what extent these genomic processes contribute to differences in cell cycle regulatory programs and cell division mechanisms among different taxonomic groups. We have undertaken a genome-wide characterization of the cell cycle genes encoded by Chlamydomonas reinhardtii, a unicellular eukaryote that is part of the green algal/land plant clade. Although Chlamydomonas cells divide by a noncanonical mechanism termed multiple fission, the cell cycle regulatory proteins from Chlamydomonas are remarkably similar to those found in higher plants and metazoans, including the proteins of the RB-E2F pathway that are absent in the fungal kingdom. Unlike in higher plants and vertebrates where cell cycle regulatory genes have undergone extensive duplication, most of the cell cycle regulators in Chlamydomonas have not. The relatively small number of cell cycle genes and growing molecular genetic toolkit position Chlamydomonas to become an important model for higher plant and metazoan cell cycles.It is well established that eukaryotic cell cycles are controlled by a conserved set of proteins. Central among these are cyclin-dependent kinases

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A novel and highly divergent Arabidopsis cyclin isolated by complementation in budding yeast

Cited by 16 publications

References 22 publications

A splice variant of cyclin D2 regulates cardiomyocyte cell cycle through a novel protein aggregation pathway

A splice variant of cyclin D2 regulates cardiomyocyte cell cycle through a novel protein aggregation pathway

Genome-Wide Analysis of the Cyclin Family in Arabidopsis and Comparative Phylogenetic Analysis of Plant Cyclin-Like Proteins

Genome-Wide Annotation and Expression Profiling of Cell Cycle Regulatory Genes in Chlamydomonas reinhardtii

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